Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Japanese population.
Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Japanese population.
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日本人群侵袭性牙周炎患者牙周病细菌的患病率。
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
I. Ishikawa
中科院分区：
文献类型：
--
作者：
Y. Takeuchi;M. Umeda;M. Ishizuka;Yi Huang;I. Ishikawa
背景
伴放线放线杆菌被认为是侵袭性牙周炎的主要病原体。其他牙周病细菌如牙龈卟啉单胞菌也被怀疑参与侵袭性牙周炎，尽管证据存在争议。本研究的目的是调查牙周致病菌的患病率，并阐明日本患者侵袭性牙周炎的微生物学特征。
方法
收集50例侵袭性牙周炎（AgP）患者的龈下菌斑（局限性10例，泛发性40例）。以35例泛发性慢性牙周炎（CP）患者和18例健康人为对照组。采用培养和聚合酶链反应（PCR）方法检测菌斑样本。
结果
A.伴放线菌在局限性AgP组（20%）和泛发性AgP组（17.5%）中的检出率较低，与对照组（CP组8.6%，健康组0%）相比无显著性差异。另一方面，在局限性和全身性侵袭性牙周炎患者中经常检测到Tannerella lasthensis（以前称为Bacteroides lasthus）、弯曲杆菌、牙龈卟啉单胞菌和齿垢密螺旋体。牙龈卟啉单胞菌的患病率和比例与局部和全身侵袭性牙周炎临床附着丧失的严重程度相关。
结论
T. Althensis，C.直肌、牙龈卟啉单胞菌和T.在日本，齿垢菌是侵袭性牙周炎患者的主要牙周致病菌。尽管A. AgP患者中还检出伴放线菌，其检出率远低于牙龈卟啉单胞菌。
BACKGROUND
Actinobacillus actinomycetemcomitans is considered a major etiologic agent of aggressive periodontitis. Other periodontopathic bacteria such as Porphyromonas gingivalis are also suspected of participating in aggressive periodontitis, although the evidence is controversial. The aim of the present study was to investigate the prevalence of periodontopathic bacteria and to clarify the microbiological features of aggressive periodontitis in Japanese patients.
METHODS
Subgingival plaque was collected from 50 aggressive periodontitis (AgP) patients (localized 10, generalized 40). Samples from 35 generalized chronic periodontitis (CP) patients and 18 healthy subjects were examined as controls. Plaque samples were examined using culture and polymerase chain reaction (PCR) method.
RESULTS
The prevalence of A. actinomycetemcomitans was relatively low in the localized (20%) and generalized (17.5%) AgP patients, with no significant difference observed in detection frequencies between AgP and the control groups (CP 8.6%, healthy 0%). On the other hand, Tannerella forsythensis (formerly Bacteroides forsythus), Campylobacter rectus, P. gingivalis, and Treponema denticola were frequently detected in localized as well as generalized aggressive periodontitis patients. The prevalence and proportion of P. gingivalis correlated with severity of clinical attachment loss in both localized and generalized aggressive periodontitis.
CONCLUSIONS
T. forsythensis, C. rectus, P. gingivalis, and T. denticola were the predominant periodontopathic bacteria of aggressive periodontitis patients in Japan. Although A. actinomycetem- comitans was also detected in AgP patients, the prevalence of this bacterium was much lower than that of P. gingivalis.
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作者：
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