Vaccination by delayed treatment of infection.
Vaccination by delayed treatment of infection.
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DOI：
10.1016/j.vaccine.2011.10.047
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发表时间：
2011-12-06
期刊：
影响因子：
5.5
通讯作者：
Antia, Rustom
中科院分区：
文献类型：
--
作者：
Stromberg, Sean P.;Antia, Rustom
有两种医疗干预措施使我们能够与传染病作斗争：可以在接触传染病之前很长时间接种疫苗，以及最常与接触传染病同时接种的抗微生物药物。在这篇论文中，我们展示了它们在原则上是如何结合起来的——先感染后治疗作为一种疫苗接种的形式。我们使用数学模型来研究如何在自然感染后适当地给予抗菌治疗，以减少感染引起的病理，并对病原体产生持久的免疫记忆。这些模型探讨了病理减少和免疫强度之间的权衡。这种权衡表明，在有限的治疗窗口期间，可以开始进行抗菌治疗，并提供疾病症状的改善和长期免疫。这种方法可能特别适合于对抗新型大流行性流感感染的出现，特别是对于个人，如在大流行的初始阶段暴露风险最大的医疗保健专业人员。
Two medical interventions allow us to combat infectious diseases: vaccination which can be administered well in advance of exposure, and antimicrobials which are most often administered contemporaneously with exposure. In this paper we show how they can, in principle, be combined – with infection followed by treatment being used as a form of vaccination. We use mathematical models to examine how appropriately administered antimicrobial treatment following natural infection can be used to reduce the pathology caused by the infection, and also generate long-lasting immunological memory to the pathogen. The models explore the tradeoff between reduction in pathology and strength of immunization. This tradeoff suggests a limited treatment window during which antimicrobial treatment can be started and provide both amelioration of disease symptoms and long-term immunity. This approach may be particularly well suited to combat the emergence of novel pandemic influenza infections particularly for individuals such as medical healthcare professionals at greatest risk for exposure during the initial stages of a pandemic.
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