Expression of the inflammatory chemokines CCL2, CCL5 and CXCL2 and the receptors CCR1-3 and CXCR2 in T lymphocytes from mammary tumor-bearing mice.
Expression of the inflammatory chemokines CCL2, CCL5 and CXCL2 and the receptors CCR1-3 and CXCR2 in T lymphocytes from mammary tumor-bearing mice.
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DOI：
10.1016/j.cellimm.2011.05.004
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发表时间：
2011
影响因子：
4.3
通讯作者：
Iragayarapu-Charyulu, Vijaya
中科院分区：
文献类型：
--
作者：
Owen, Jennifer L.;Criscitiello, Michael F.;Libreros, Stephania;Garcia-Areas, Ramon;Guthrie, Kathleen;Torroella-Kouri, Marta;Iragayarapu-Charyulu, Vijaya
趋化因子及其受体已在几种实体瘤模型中作为炎症介质进行了研究。反过来，炎症与肿瘤的促进和进展有关，因此，趋化因子已被提出作为化疗的新分子靶点。虽然这些分子的表达已被描述在肿瘤细胞，内皮细胞，巨噬细胞，和中性粒细胞，较少关注这些分子的表达谱的T淋巴细胞在外周或浸润的肿瘤。使用D1-DMBA-3小鼠乳腺癌模型，我们旨在更好地表征宿主和肿瘤微环境中趋化因子和/或其受体的差异表达，特别是与正常对照动物相比，荷瘤小鼠的T细胞中的差异表达。我们发现荷瘤小鼠的T淋巴细胞表达促炎趋化因子CCL 2、CCL 5和CXCL 2，以及趋化因子受体CCR 1、CCR 2、CCR 3和CXCR 2。
Chemokines and their receptors have been studied in several solid tumor models as mediators of inflammation. In turn, inflammation has been implicated in the promotion and progression of tumors, and as such, chemokines have been proposed as novel molecular targets for chemotherapy. While the expression of these molecules has been described in tumor cells, endothelial cells, macrophages, and neutrophils, less attention has been paid to the expression profile of these molecules by T lymphocytes in the periphery or infiltrating the tumor. Using the D1-DMBA-3 murine mammary adenocarcinoma model, we aimed to better characterize the differential expression of chemokines and/or their receptors in the host and in the tumor microenvironment, and specifically, in the T cells of tumor-bearing mice compared to normal control animals. We found that T lymphocytes from tumor-bearing mice express the pro-inflammatory chemokines, CCL2, CCL5, and CXCL2, as well as the chemokine receptors, CCR1, CCR2, CCR3 and CXCR2.
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DOI：
10.1186/bcr554
发表时间：
2003
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Ben-Baruch A
通讯作者：
Ben-Baruch A
影响因子：
5.4
作者：
JULIUS, MH;SIMPSON, E;HERZENBERG, LA
通讯作者：
HERZENBERG, LA
影响因子：
64.8
作者：
Baggiolini, M
通讯作者：
Baggiolini, M
影响因子：
3.8
作者：
Campbell, MJ;Scott, J;Esserman, LJ
通讯作者：
Esserman, LJ
影响因子：
11.5
作者：
Benoy, IH;Salgado, R;Dirix, LY
通讯作者：
Dirix, LY