Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band
Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band
复制标题
强直阵挛发作中与高频活动耦合的频段从 θ 频段转移到 δ 频段
DOI：
10.1016/j.clinph.2022.02.015
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发表时间：
2022
影响因子：
4.7
通讯作者：
Kishima Haruhiko
中科院分区：
文献类型：
--
作者：
Hashimoto Hiroaki;Khoo Hui Ming;Yanagisawa Takufumi;Tani Naoki;Oshino Satoru;Hirata Masayuki;Kishima Haruhiko
目的阐明高频活动（HFA）和低频带之间的关系，从强直阵挛阶段局灶性双侧强直阵挛发作（FBTCS），使用相位振幅coupling.MethodsThis回顾性研究纳入了6例耐药局灶性癫痫患者在大坂大学医院接受颅内电极放置（2018年7月至2019年7月）。我们记录了11个FBTCS。结果在强直相，θ波（4- 8Hz）与HFA的耦合达到峰值，HFA功率出现在θ波的基线（0 μV）。而在阵挛相，δ（2-4 Hz）-HFA耦合达到峰值，HFA功率出现在δ振荡的低谷。ROC分析表明，δ-HFA SI可以很好地区分阵挛性发作和强直性发作。结论调制HFA的主要低频带从强直性发作的θ带转移到阵挛性发作的δ带。意义暗示神经生理关键频带分别是强直性发作和阵挛性发作的θ带和δ带，这提高了我们对FBTCS的认识。
ObjectiveTo clarify variations in the relationship between high-frequency activities (HFAs) and low-frequency bands from the tonic to the clonic phase in focal to bilateral tonic-clonic seizures (FBTCS), using phase-amplitude coupling.MethodsThis retrospective study enrolled six patients with drug-resistant focal epilepsy who underwent intracranial electrode placement at Osaka University Hospital (July 2018–July 2019). We recorded 11 FBTCS. The synchronization index (SI) and receiver-operating characteristic (ROC) analysis were used to analyze the coupling between HFA amplitude (80–250 Hz) and lower frequencies phase.ResultsIn the tonic phase, the θ (4–8 Hz)-HFA coupling peaked, and the HFA power occurred at baseline (0 μV) of θ oscillations. In contrast, in the clonic phase, the δ (2–4 Hz)-HFA coupling peaked, and the HFA power occurred at the trough of δ oscillations. ROC analysis indicated that the δ-HFA SI discriminated well the clonic from the tonic phase.ConclusionsThe main low-frequency band modulating the HFA shifted from the θ band in the tonic phase to the δ band in the clonic phase.SignificanceNeurophysiological key frequency bands were implied to be the θ band and δ band in tonic and clonic seizures, respectively, which improves our understanding of FBTCS.
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