Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases.
Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases.
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DOI：
10.1289/ehp.10200
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发表时间：
2007-09
影响因子：
10.4
通讯作者：
Reinlib L
中科院分区：
文献类型：
--
作者：
Stevens RG;Blask DE;Brainard GC;Hansen J;Lockley SW;Provencio I;Rea MS;Reinlib L
光，包括人造光，对人类的生理和行为有一系列的影响，因此在不适当的时间会改变人类的生理。光诱导的潜在干扰的一个例子是光对昼夜节律的影响，包括产生几种激素节律。明暗暴露的变化(例如，非白天工作或跨子午线旅行)改变了昼夜节律系统的时间，使内部节奏与外部环境和内部彼此失去同步，损害了我们在适当时间睡眠和醒来的能力，并损害了生理和新陈代谢过程。光还可以对神经内分泌系统产生直接的急性影响，例如，抑制褪黑素的合成或增加皮质醇的产生，这可能会产生不良的长期后果。出于这些原因，国家环境健康科学研究所召集了一个由不同科学家组成的研讨会，以考虑如何最好地对照明与健康之间可能存在的联系进行研究。根据研讨会的与会者的说法，有三个广泛的研究领域需要解决。首先是光传导对昼夜节律、神经内分泌和神经行为调节的基本生物物理和分子遗传学机制。其次是扰乱这些昼夜节律调节过程的可能的生理后果，如激素的产生，特别是褪黑素的产生，以及正常和肿瘤组织的生长动态。三是光诱导的生理干扰对疾病发生和预后的影响，以及如何通过应用这些知识来改进预防和治疗。
Light, including artificial light, has a range of effects on human physiology and behavior and can therefore alter human physiology when inappropriately timed. One example of potential light-induced disruption is the effect of light on circadian organization, including the production of several hormone rhythms. Changes in light–dark exposure (e.g., by nonday occupation or transmeridian travel) shift the timing of the circadian system such that internal rhythms can become desynchronized from both the external environment and internally with each other, impairing our ability to sleep and wake at the appropriate times and compromising physiologic and metabolic processes. Light can also have direct acute effects on neuroendocrine systems, for example, in suppressing melatonin synthesis or elevating cortisol production that may have untoward long-term consequences. For these reasons, the National Institute of Environmental Health Sciences convened a workshop of a diverse group of scientists to consider how best to conduct research on possible connections between lighting and health. According to the participants in the workshop, there are three broad areas of research effort that need to be addressed. First are the basic biophysical and molecular genetic mechanisms for phototransduction for circadian, neuroendocrine, and neurobehavioral regulation. Second are the possible physiologic consequences of disrupting these circadian regulatory processes such as on hormone production, particularly melatonin, and normal and neoplastic tissue growth dynamics. Third are effects of light-induced physiologic disruption on disease occurrence and prognosis, and how prevention and treatment could be improved by application of this knowledge.
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