Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease.
Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease.
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阿尔茨海默病和帕金森病的神经递质受体和认知功能障碍
DOI：
10.1016/j.pneurobio.2012.02.002
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发表时间：
2012-04
影响因子：
6.7
通讯作者：
Wang, Qing
中科院分区：
文献类型：
--
作者：
Xu, Yunqi;Yan, Junqiang;Zhou, Peng;Li, Jiejie;Gao, Huimin;Xia, Ying;Wang, Qing
认知功能障碍是阿尔茨海默病、帕金森病（晚期）等多种神经退行性疾病最典型的特征之一。尽管神经元凋亡和炎症反应等多种机制已被认为与这些疾病中认知功能障碍的发病机制有关，但最近对神经变性和认知功能障碍的研究表明受体调节对认知变化具有显着影响。各种受体的病理改变似乎导致认知障碍和/或恶化，并与多种机制相关。本文概述了目前对人类不同受体调节以及阿尔茨海默病和帕金森病的各种实验模型的理解和概念，以及对潜在机制的概念更新。将以互动方式讨论血清素、肾上腺素、乙酰胆碱、多巴胺受体和 N-甲基-D-天冬氨酸受体在阿尔茨海默病和帕金森病中的具体作用。与神经退行性疾病相关的认知功能障碍中涉及信号通路的复杂机制也将得到解决。大量证据表明，这些受体是导致认知病理学的重要神经调节器，并且这些受体与认知能力表达之间存在复杂的相关性。因此，受体的病理改变将导致阿尔茨海默病和帕金森病的认知障碍和/或恶化。未来的研究可能会通过针对额叶-纹状体、额-纹状体-丘脑和中边缘回路中这些受体及其信号转导途径的特定改变，为治疗神经退行性疾病认知功能障碍提供新线索。
Cognitive dysfunction is one of the most typical characteristics in various neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease (advanced stage). Although several mechanisms like neuronal apoptosis and inflammatory responses have been recognized to be involved in the pathogenesis of cognitive dysfunction in these diseases, recent studies on neurodegeneration and cognitive dysfunction have demonstrated a significant impact of receptor modulation on cognitive changes. The pathological alterations in various receptors appear to contribute to cognitive impairment and/or deterioration with correlation to diversified mechanisms. This article recapitulates the present understandings and concepts underlying the modulation of different receptors in human beings and various experimental models of Alzheimer’s disease and Parkinson’s disease as well as a conceptual update on the underlying mechanisms. Specific roles of serotonin, adrenaline, acetylcholine, dopamine receptors, and N-methyl-D-aspartate receptors in Alzheimer’s disease and Parkinson’s disease will be interactively discussed. Complex mechanisms involved in their signaling pathways in the cognitive dysfunction associated with the neurodegenerative diseases will also be addressed. Substantial evidence has suggested that those receptors are crucial neuroregulators contributing to cognitive pathology and complicated correlations exist between those receptors and the expression of cognitive capacities. The pathological alterations in the receptors would, therefore, contribute to cognitive impairments and/or deterioration in Alzheimer’s disease and Parkinson’s disease. Future research may shed light on new clues for the treatment of cognitive dysfunction in neurodegenerative diseases by targeting specific alterations in these receptors and their signal transduction pathways in the frontal-striatal, fronto–striato–thalamic, and mesolimbic circuitries.
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影响因子：
5.3
作者：
Bitner, Robert S.;Bunnelle, William H.;Gopalakrishnan, Murali
通讯作者：
Gopalakrishnan, Murali
影响因子：
16.2
作者：
Chang, KT;Berg, DK
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Berg, DK
影响因子：
11
作者：
Cheesman, AL;Barker, RA;Brooks, DJ
通讯作者：
Brooks, DJ
影响因子：
2.6
作者：
Costa, Alberto;Peppe, Antonella;Carlesimo, Giovanni Augusto
通讯作者：
Carlesimo, Giovanni Augusto
影响因子：
2.9
作者：
CASH, R;RUBERG, M;AGID, Y
通讯作者：
AGID, Y