Anatomical connections between the anterior and posterodorsal sub-regions of the medial amygdala: integration of odor and hormone signals.
Anatomical connections between the anterior and posterodorsal sub-regions of the medial amygdala: integration of odor and hormone signals.
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DOI：
10.1016/j.neuroscience.2010.06.075
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发表时间：
2010-10-13
期刊：
影响因子：
3.3
通讯作者：
Petrulis, A.
中科院分区：
文献类型：
--
作者：
Maras, P. M.;Petrulis, A.
在许多啮齿动物物种中，如叙利亚仓鼠，生殖行为需要化学感受信息和类固醇激素线索的神经整合。内侧杏仁核通过解剖学上不同的子区域处理这两种信号;前区（MeA）接收大量的化学感受输入，但包含很少的类固醇受体标记的神经元，而后背区（MePD）接收较少的化学感受输入，但包含密集的雄激素和雌激素受体。重要的是，这些子区域有相当大的相互联系，我们实验室以前的研究表明，MeA和MePD之间的功能相互作用是研究雄性仓鼠异性气味的偏好所必需的。因此，我们假设化学感觉和激素信号直接在MeA和MePD之间传递。为了验证这一假设，我们将逆行示踪剂霍乱毒素B（CTB）注射到男性受试者的MeA或MePD中，并确定MePD或MeA中的逆行标记细胞是否分别表达（1）暴露于女性或男性气味后的Fos蛋白或（2）雄激素受体（AR）。在MeA中，大约36%的CTB标记细胞（投射到MePD）在暴露于任何一种社会气味后也表达Fos，相比之下，MePD中只有13%的CTB标记细胞（投射到MeA）也表达气味诱导的Fos。相比之下，MePD中57%的CTB标记细胞也含有AR，而MeA中28%的CTB标记细胞为AR/CTB双标记。这些结果提供了第一个解剖学证据表明，化学感觉和激素线索之间的MeA和MePD直接传达。此外，这些数据表明，化学感觉信息主要从MeA传递到MePD，而激素信息主要从MePD传递到MeA。更广泛地说，MeA和MePD之间的相互作用可能代表了一种基本机制，通过这种机制，大脑将环境中有关社会线索的信息与生殖状态的激素指数整合在一起。
In many rodent species, such as Syrian hamsters, reproductive behavior requires neural integration of chemosensory information and steroid hormone cues. The medial amygdala processes both of these signals through anatomically distinct sub-regions; the anterior region (MeA) receives substantial chemosensory input, but contains few steroid receptor-labeled neurons, whereas the posterodorsal region (MePD) receives less chemosensory input, but contains dense populations of androgen and estrogen receptors. Importantly, these sub-regions have considerable reciprocal connections, and previous studies in our lab have shown that functional interactions between MeA and MePD are required for the preference to investigate opposite-sex odors in male hamsters. We therefore hypothesized that chemosensory and hormone signals are conveyed directly between MeA and MePD. To test this hypothesis, we injected the retrograde tracer, cholera toxin B (CTB), into either MeA or MePD of male subjects and identified whether retrogradely labeled cells within MePD or MeA, respectively, expressed (1) Fos protein following exposure to female or male odors or (2) androgen receptors (AR). Approximately 36% of CTB-labeled cells within MeA (that project to MePD) also expressed Fos following exposure to either social odor, compared to the only 13% of CTB-labeled cells within MePD (that project to MeA) that also expressed odor-induced Fos. In contrast, 57% of CTB-labeled cells within MePD also contained AR, compared to the 28% of CTB-labeled cells within MeA that were double-labeled for AR/CTB. These results provide the first anatomical evidence that chemosensory and hormone cues are conveyed directly between MeA and MePD. Furthermore, these data suggest that chemosensory information is conveyed primarily from MeA to MePD, whereas hormone information is conveyed primarily from MePD to MeA. More broadly, the interactions between MeA and MePD may represent a basic mechanism by which the brain integrates information about social cues in the environment with hormonal indices of reproductive state.
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影响因子：
1.7
作者：
Delville, Y;De Vries, GJ;Ferris, CF
通讯作者：
Ferris, CF
影响因子：
3.5
作者：
Fiber, JM;Swann, JM
通讯作者：
Swann, JM
影响因子：
2.5
作者：
Creutz, LM;Kritzer, MF
通讯作者：
Kritzer, MF
DOI：
10.1073/pnas.0901130106
发表时间：
2009-06-16
影响因子：
11.1
作者：
Gowaty, Patricia Adair;Hubbell, Stephen P.
通讯作者：
Hubbell, Stephen P.
DOI：
10.1016/0022-4731(76)90051-0
发表时间：
1976-01-01
影响因子：
4.1
作者：
BEYER, C;MORALI, G;SODERSTEN, P
通讯作者：
SODERSTEN, P