Characterization of TRPC2, an essential genetic component of VNS chemoreception, provides insights into the evolution of pheromonal olfaction in secondary-adapted marine mammals.
Characterization of TRPC2, an essential genetic component of VNS chemoreception, provides insights into the evolution of pheromonal olfaction in secondary-adapted marine mammals.
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TRPC2 是 VNS 化学感受的重要遗传成分，其特征为了解次级适应海洋哺乳动物信息素嗅觉的进化提供了见解。
DOI：
10.1093/molbev/msq027
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发表时间：
2010
影响因子：
10.7
通讯作者：
Ya
中科院分区：
文献类型：
--
作者：
Li Yu;Wei Jin;Jia;Xin Zhang;Meng;Zhou;Hang;Mu;Ya
信息素是由同一物种的个体释放和感知的化学信号，在调节哺乳动物的生殖和社会行为中具有重要作用。通常，它们由犁鼻系统（VNS）检测。在这里，我们首先研究并比较了四种水生专门化程度不同的海洋哺乳动物和相关陆地物种犁鼻化学感受的一个重要遗传成分，即TRPC 2基因，以深入了解信息素嗅觉的进化。哺乳动物从陆地过渡到水中。我们的结果基于序列特征和进化分析，首次显示了完全水生鲸类犁鼻信息素信号转导通路的祖先损伤的证据，支持由于完全适应海洋栖息地而减少或不依赖嗅觉，而两栖加州海狮被发现具有pupsively功能性TRPC 2基因，这仍然是在强大的选择压力，反映了陆地环境的依赖化学识别之间的半适应海洋哺乳动物。有趣的是，我们的研究发现，与加州海狮不同，同样是半水生动物的斑海豹和水獭的TRPC 2基因是假基因。我们的数据表明，其他未知的选择性压力或感觉方式可能促进了独立的情况下，在这两个物种的功能性VNS。在这方面，海洋哺乳动物信息素嗅觉的进化似乎比以前认为的更复杂和混乱。我们的研究作出了有益的贡献，目前的理解的进化信息素感知的哺乳动物在选择压力从水生环境。
Pheromones are chemical cues released and sensed by individuals of the same species, which are of major importance in regulating reproductive and social behaviors of mammals. Generally, they are detected by the vomeronasal system (VNS). Here, we first investigated and compared an essential genetic component of vomeronasal chemoreception, that is, TRPC2 gene, of four marine mammals varying the degree of aquatic specialization and related terrestrial species in order to provide insights into the evolution of pheromonal olfaction in the mammalian transition from land to water. Our results based on sequence characterizations and evolutionary analyses, for the first time, show the evidence for the ancestral impairment of vomeronasal pheromone signal transduction pathway in fully aquatic cetaceans, supporting a reduced or absent dependence on olfaction as a result of the complete adaptation to the marine habitat, whereas the amphibious California sea lion was found to have a putatively functional TRPC2 gene, which is still under strong selective pressures, reflecting the reliance of terrestrial environment on chemical recognition among the semiadapted marine mammals. Interestingly, our study found that, unlike that of the California sea lion, TRPC2 genes of the harbor seal and the river otter, both of which are also semiaquatic, are pseudogenes. Our data suggest that other unknown selective pressures or sensory modalities might have promoted the independent absence of a functional VNS in these two species. In this respect, the evolution of pheromonal olfaction in marine mammals appears to be more complex and confusing than has been previously thought. Our study makes a useful contribution to the current understanding of the evolution of pheromone perception of mammals in response to selective pressures from an aquatic environment.
影响因子：
2.5
作者：
Xu, FQ;Schaefer, M;Shepherd, GM
通讯作者：
Shepherd, GM
影响因子：
3.5
作者：
Restrepo, D;Arellano, J;Lin, WH
通讯作者：
Lin, WH
影响因子：
7
作者：
Young, JM;Kambere, M;Lane, RP
通讯作者：
Lane, RP