Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.
Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.
复制标题
DOI：
10.3109/13547500903186452
复制
发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Vineis P
中科院分区：
文献类型：
--
作者：
Rundle A;Richie J;Steindorf K;Peluso M;Overvad K;Raaschou-Nielsen O;Clavel-Chapelon F;Linseisen JP;Boeing H;Trichopoulou A;Palli D;Krogh V;Tumino R;Panico S;Bueno-De-Mesquita HB;Peeters PH;Lund E;Gonzalez CA;Martinez C;Dorronsoro M;Barricarte A;Tormo MJ;Quiros J;Agudo A;Berglund G;Jarvholm B;Bingham S;Key TJ;Gormally E;Saracci R;Kaaks R;Riboli E;Vineis P
在欧洲癌症和营养前瞻性研究中，对230例病例和648例对照进行了一项研究，研究了体力活动、潜在的中间生物标志物和肺癌风险之间的关系。通过32 P后标记获得的白色血细胞芳香族DNA加合物和红细胞中谷胱甘肽（GSH）的数据可从病例和对照组的子集中获得。与第一个四分位数相比，第四个四分位数的娱乐性体力活动与较低的肺癌风险[比值比=0.56（0.35-0.90）]，较高的GSH水平[+1.87微摩尔GSH/克血红蛋白，p=0.04]相关，但与高水平加合物的存在无关[比值比=1.05（0.38-2.86）]。尽管与娱乐性体力活动有关，但在这些小规模的初步分析中，谷胱甘肽水平与肺癌风险无关，[比值比=0.95（0.84 - 1.07）谷胱甘肽水平每单位增加]。家庭和职业活动与肺癌风险或生物标志物水平无关。
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-postlabeling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared to the first quartile, the fourth quartile of recreational physical activity was associated with lower lung cancer risk [odds ratio=0.56 (0.35–0.90)], higher GSH levels [+1.87 micro mole GSH/gram haemoglobin, p=0.04] but not with the presence of high levels of adducts [odds ratio=1.05 (0.38–2.86)]. Despite being associated with recreational physical activity, in these small scale pilot analyses GSH levels were not associated with lung cancer risk, [odds ratio=0.95 (0.84 – 1.07) per unit increase in glutathione levels]. Household and occupational activity was not associated with lung cancer risk or biomarker levels.
登录
查看更多内容
DOI：
10.1007/bf00636224
发表时间：
1992-04-01
期刊：
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY
影响因子：
--
作者：
EVELO, CTA;PALMEN, NGM;JANSSEN, GME
通讯作者：
JANSSEN, GME
影响因子：
5
作者：
Bowles, HR;Fitzgerald, SJ;Blair, SN
通讯作者：
Blair, SN
影响因子：
2.7
作者：
Garrett, NA;Alesci, NL;Manley, MW
通讯作者：
Manley, MW
影响因子：
3.8
作者：
Airoldi, L;Vineis, P;Riboli, E
通讯作者：
Riboli, E
影响因子：
50.5
作者：
Ferlay, J.;Autier, P.;Boyle, P.
通讯作者：
Boyle, P.