Long-acting methylphenidate has an effect on aggressive behavior in children with attention-deficit/hyperactivity disorder.
Long-acting methylphenidate has an effect on aggressive behavior in children with attention-deficit/hyperactivity disorder.
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长效哌醋甲酯对注意力缺陷/多动症儿童的攻击行为有影响。
DOI：
10.1089/cap.2007.0011
复制
发表时间：
2007
影响因子：
1.9
通讯作者：
R. Fischer
中科院分区：
文献类型：
--
作者：
J. Sinzig;M. Döpfner;G. Lehmkuhl;H. Uebel;K. Schmeck;F. Poustka;W. Gerber;M. Günter;U. Knölker;M. Gehrke;F. Hässler;F. Resch;M. Brünger;C. Ose;R. Fischer
简介
患有注意力缺陷/多动障碍 (ADHD) 的儿童和青少年经常出现攻击行为。本研究的目的是评估一种新型长效哌醋甲酯制剂（Medikinetretard，MPH-MR）在抵抗和攻击行为方面的功效，该制剂具有等量的速释和缓释活性物质，特别是观察教师或家长对攻击行为的评估与 ADHD 亚症状之间的相关性。
方法
根据《精神疾病诊断与统计手册》第四版 (DSM-IV)，使用 ADHD、对立违抗和品行障碍症状检查表，对 85 名儿童和青少年（6-16 岁）进行了为期 5 周的双盲、随机临床试验，接受 MPH-MR 治疗。
结果
共有64.9%的儿童表现出对立违抗障碍/品行障碍（ODD/CD）症状。在 MPH 治疗组（verum 组）中发现了统计学上显着的效果。根据科恩的标准，在学校（d = 1.0）中发现攻击性症状的影响较大，但在下午则不然（d = 0.4）。对于更严重的侵袭性症状，效应值也较小。我们发现 ODD/CD 症状与 ADHD 子量表多动/冲动与注意力不集中子量表之间存在特征相关性。
结论
长效 MPH 可有效治疗对抗性挑衅和攻击行为，尤其是较轻微的症状。冲动性和攻击性之间的预期相关性可以得到证实。
INTRODUCTION
Aggression is frequently observed in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). The aim of this study was to assess the efficacy with regard to oppositional and aggressive behavior of a new long-acting methylphenidate preparation (Medikinet retard, MPH-MR), with equal portions of the immediate-release and the sustained-release active substance, and especially to look at correlations between either teacher or parent assessment of aggression and ADHD sub-symptomatology.
METHODS
Eighty five children and adolescents (6-16 years) were investigated in a double-blind, randomized, clinical trial over 5 weeks under a treatment with MPH-MR using symptom checklists for ADHD, oppositional-defiant and conduct disorder according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV).
RESULTS
A total of 64.9% of the children showed oppositional defiant disorder/conduct disorder (ODD/CD) symptoms. A statistically significant effect was found in the group treated with MPH (verum-group). On the basis of Cohen's criteria, high effects were found for aggressive symptoms in school (d = 1.0), but not in the afternoon (d = 0.4). There were also lower effect sizes for more severe aggressive symptoms. We found characteristic correlations between ODD/CD symptoms and the ADHD subscale hyperactivity/impulsivity compared to the subscale inattention.
CONCLUSIONS
Long-acting MPH is effective in the treatment of oppositional-defiant and aggressive behavior, especially concerning milder symptoms. The expected correlation between impulsivity and aggressiveness could be confirmed.
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患有多动症的男孩的血浆皮质醇和攻击性。
DOI：
10.1097/00004583-199705000-00010
发表时间：
1997
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry.
影响因子：
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作者：
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DOI：
10.1089/cap.1997.7.87
发表时间：
1997
期刊：
Journal of child and adolescent psychopharmacology.
影响因子：
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作者：
Riggs,PD;Mikulich,SK;Coffman,LM;Crowley,TJ
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DOI：
10.1097/00004583-200102000-00013
发表时间：
2001-02-01
影响因子：
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DOI：
10.1097/00004583-199504000-00011
发表时间：
1995-04-01
影响因子：
13.3
作者：
CAMPBELL, M;ADAMS, PB;OVERALL, JE
通讯作者：
OVERALL, JE