The Pig as a Translational Animal Model for Biobehavioral and Neurotrauma Research.
The Pig as a Translational Animal Model for Biobehavioral and Neurotrauma Research.
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猪作为生物行为和神经创伤研究的转化动物模型。
DOI：
10.3390/biomedicines11082165
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发表时间：
2023-08-01
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
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作者：
近几十年来，由于猪和人类的神经解剖学、生理学和行为学之间的主要相似性，猪作为转化生物行为研究中的重要中介模型动物引起了相当大的关注。因此，人们越来越有兴趣使用猪来模拟许多人类神经系统疾病和损伤。猪非常聪明，能够进行各种行为，这可以为各种神经疾病状态的影响提供有价值的见解。在神经创伤研究领域，猪已经成为一个特别相关的模式物种。事实上，开发猪损伤模型和评估治疗方案的研究人员数量正在不断扩大。在这篇综述中，我们研究了猪的认知和行为研究以及一些常用的生理评估方法。我们还讨论了目前使用猪作为模型的研究创伤性脑损伤。我们的结论是，猪是一种有价值的动物物种，用于研究认知和疾病的生理影响，它有可能为人类神经和精神疾病的新治疗和疗法的发展做出贡献。
In recent decades, the pig has attracted considerable attention as an important intermediary model animal in translational biobehavioral research due to major similarities between pig and human neuroanatomy, physiology, and behavior. As a result, there is growing interest in using pigs to model many human neurological conditions and injuries. Pigs are highly intelligent and are capable of performing a wide range of behaviors, which can provide valuable insight into the effects of various neurological disease states. One area in which the pig has emerged as a particularly relevant model species is in the realm of neurotrauma research. Indeed, the number of investigators developing injury models and assessing treatment options in pigs is ever-expanding. In this review, we examine the use of pigs for cognitive and behavioral research as well as some commonly used physiological assessment methods. We also discuss the current usage of pigs as a model for the study of traumatic brain injury. We conclude that the pig is a valuable animal species for studying cognition and the physiological effect of disease, and it has the potential to contribute to the development of new treatments and therapies for human neurological and psychiatric disorders.
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影响因子：
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作者：
Flood AB;Wood VA;Schreiber W;Williams BB;Gallez B;Swartz HM
通讯作者：
Swartz HM
影响因子：
1.9
作者：
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通讯作者：
King, Albert I.
DOI：
10.1098/rspb.1967.0002
发表时间：
1967-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DICKERSON, JW;DOBBING, J
通讯作者：
DOBBING, J
DOI：
10.1007/7854_2014_329
发表时间：
2015-01-01
期刊：
ETHICAL ISSUES IN BEHAVIORAL NEUROSCIENCE
影响因子：
--
作者：
Bovenkerk, Bernice;Kaldewaij, Frederike
通讯作者：
Kaldewaij, Frederike
影响因子：
2.5
作者：
DOBBING, J;SANDS, J
通讯作者：
SANDS, J