Effects of an HIV peer prevention intervention on sexual and injecting risk behaviors among injecting drug users and their risk partners in Thai Nguyen, Vietnam: a randomized controlled trial.
Effects of an HIV peer prevention intervention on sexual and injecting risk behaviors among injecting drug users and their risk partners in Thai Nguyen, Vietnam: a randomized controlled trial.
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DOI：
10.1016/j.socscimed.2013.07.006
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发表时间：
2013-11
影响因子：
5.4
通讯作者：
Vu Minh Quan
中科院分区：
文献类型：
--
作者：
Go, Vivian F.;Frangakis, Constantine;Nguyen Le Minh;Latkin, Carl A.;Tran Viet Ha;Tran Thi Mo;Sripaipan, Teerada;Davis, Wendy;Zelaya, Carla;Pham The Vu;Chen, Yong;Celentano, David D.;Vu Minh Quan
在全球范围内，撒哈拉以南非洲地区以外的新艾滋病毒感染者中有 30% 涉及注射吸毒者 (IDU)，并且在包括越南在内的许多国家，艾滋病毒流行集中在注射吸毒者中。我们在越南太原进行了一项随机对照试验，以评估以同伴为导向的行为干预是否可以减少注射吸毒者及其网络成员中的注射和性艾滋病毒危险行为。纳入了 419 名 18 岁或以上 HIV 阴性指数注射吸毒者和 516 名注射和性网络成员。除了 HIV 检测和咨询 (HTC)（干预；n = 210）或仅接受 HTC（对照；n = 209）之外，每个指数参与者被随机分配接受一系列六次小组同伴教育培训课程和三次加强课程。干预后 3、6、9 和 12 个月进行随访，包括 HTC。在所有指数网络成员对中，基线和 3 个月访问期间无保护性行为的比例从 49% 显着下降至 27%（SE（差异）= 3%，p < 0.01）。然而，在干预后 12 个月时，相对于对照组参与者，干预参与者的无保护性行为下降幅度更大（Wald 检验 = 10.8，df = 4，p = 0.03）。这种干预效应的解释是，分配到对照组的试验参与者在随访期间至少错过了一次标准化 HTC 课程，随后报告称无保护性行为有所增加。观察到的针头/注射器共用比例在基线和 3 个月就诊期间显着下降（14% 与 3%，SE（差异）= 2%，p < 0.01），并持续到 12 个月，但试验组之间没有差异（Wald 检验 = 3.74，df = 3，p = 0.44）。
Globally, 30% of new HIV infections outside sub-Saharan Africa involve injecting drug users (IDU) and in many countries, including Vietnam, HIV epidemics are concentrated among IDU. We conducted a randomized controlled trial in Thai Nguyen, Vietnam, to evaluate whether a peer oriented behavioral intervention could reduce injecting and sexual HIV risk behaviors among IDU and their network members. 419 HIV-negative index IDU aged 18 years or older and 516 injecting and sexual network members were enrolled. Each index participant was randomly assigned to receive a series of six small group peer educator-training sessions and three booster sessions in addition to HIV testing and counseling (HTC) (intervention; n = 210) or HTC only (control; n = 209). Follow-up, including HTC, was conducted at 3, 6, 9 and 12 months post-intervention. The proportion of unprotected sex dropped significantly from 49% to 27% (SE (difference) = 3%, p < 0.01) between baseline and the 3-month visit among all index-network member pairs. However, at 12 months, post-intervention, intervention participants had a 14% greater decline in unprotected sex relative to control participants (Wald test = 10.8, df = 4, p = 0.03). This intervention effect is explained by trial participants assigned to the control arm who missed at least one standardized HTC session during follow-up and subsequently reported increased unprotected sex. The proportion of observed needle/syringe sharing dropped significantly between baseline and the 3-month visit (14% vs. 3%, SE (difference) = 2%, p < 0.01) and persisted until 12 months, but there was no difference across trial arms (Wald test = 3.74, df = 3, p = 0.44).
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影响因子：
120.7
作者：
Ball, K;Berch, DB;Willis, SL
通讯作者：
Willis, SL
影响因子：
168.9
作者：
Mathers, Bradley M.;Degenhardt, Louisa;Mattick, Richard P.
通讯作者：
Mattick, Richard P.
影响因子：
4.2
作者：
Kapadia, F.;Latka, M. H.;Garfein, R. S.
通讯作者：
Garfein, R. S.
DOI：
10.1097/qai.0b013e3181d61def
发表时间：
2010-06
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
NIMH Collaborative HIV/STD Prevention Trial Group
通讯作者：
NIMH Collaborative HIV/STD Prevention Trial Group
影响因子：
3.8
作者：
JARLAIS, DCD;FRIEDMAN, SR;TELLES, PR
通讯作者：
TELLES, PR