Regular Leisure-Time Physical Activity is Effective in Boosting Neurotrophic Factors and Alleviating Menopause Symptoms.
Regular Leisure-Time Physical Activity is Effective in Boosting Neurotrophic Factors and Alleviating Menopause Symptoms.
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DOI：
10.3390/ijerph17228624
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发表时间：
2020-11-20
影响因子：
--
通讯作者：
Kang S
中科院分区：
文献类型：
--
作者：
Kim B;Kang S
背景资料：本研究调查了有规律的休闲体育活动对肥胖中年妇女认知功能参数（血浆脑源性神经营养因子（BDNF）、神经生长因子（NGF）和组织蛋白酶B）和更年期症状（更年期、抑郁和认知障碍）的影响。方法：所有受试者均为中年肥胖女性（n = 52，体脂%> 30%）。研究对象分为绝经前（PRM）组（n = 18，年龄= 47.56 ± 6.11岁）和绝经后（POM）组（n = 34，年龄= 57.79 ± 5.68岁）。参与者完成了一份与抑郁症和更年期有关的调查问卷，以及认知测试。体力活动进行了12周。禁食12小时后分析前臂静脉血样。使用R&D试剂盒分析BDNF、NGF和组织蛋白酶B的血液水平。结果如下：规律的闲暇时间体育活动对降低绝经前和绝经后肥胖妇女的体脂百分比有积极作用。此外，问卷调查结果显示，经常锻炼对生活方式改变引起的身体成分有积极作用，并增强了心理稳定性。绝经后肥胖妇女的BDNF浓度显著低于绝经前肥胖妇女。此外，定期体力活动显着增加组织蛋白酶B和神经生长因子水平在绝经后肥胖妇女。结论：在韩国肥胖妇女中，持续的闲暇时间体力活动改善了身体成分和神经营养因子，减轻了更年期症状。
Background: The study investigated the effects of regular leisure-time physical activity on the parameters of cognitive function (plasma brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and cathepsin B) and menopausal symptoms (the climacterium, depression, and cognitive impairment) in obese middle-aged women. Methods: All subjects were middle-aged and obese women (n = 52, % body fat > 30%). The participants were divided into premenopausal (PRM) (n = 18, age = 47.56 ± 6.11 years) and postmenopausal (POM) (n = 34, age = 57.79 ± 5.68 years) groups. The participants completed a survey questionnaire related to depression and the climacterium, as well as cognitive tests. Physical activity was performed for 12 weeks. Blood samples from the forearm vein were analyzed after 12 h of fasting. Blood levels of BDNF, NGF, and cathepsin B were analyzed using an R&D kit. Results: Regular leisure-time physical activity had a positive effect on reducing the percentage of body fat in premenopausal and postmenopausal obese women. In addition, the results of the questionnaire showed that regular exercise had a positive effect on body composition caused by lifestyle change and enhanced psychological stability. The BDNF concentration was significantly lower in postmenopausal than in premenopausal obese women. In addition, regular physical activity significantly increased the cathepsin B and NGF levels in postmenopausal obese women. Conclusions: Continuous leisure-time physical activity improved body composition and neurotrophic factors and alleviated menopausal symptoms in obese Korean women.
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影响因子：
12.7
作者：
Gold, Ellen B.;Colvin, Alicia;Matthews, Karen
通讯作者：
Matthews, Karen
影响因子：
39.3
作者：
Healy, Genevieve N.;Matthews, Charles E.;Owen, Neville
通讯作者：
Owen, Neville
影响因子：
4.9
作者：
Elavsky, S;McAuley, E
通讯作者：
McAuley, E
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
DOI：
10.3945/ajcn.114.100065
发表时间：
2015-03
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Ekelund U;Ward HA;Norat T;Luan J;May AM;Weiderpass E;Sharp SJ;Overvad K;Østergaard JN;Tjønneland A;Johnsen NF;Mesrine S;Fournier A;Fagherazzi G;Trichopoulou A;Lagiou P;Trichopoulos D;Li K;Kaaks R;Ferrari P;Licaj I;Jenab M;Bergmann M;Boeing H;Palli D;Sieri S;Panico S;Tumino R;Vineis P;Peeters PH;Monnikhof E;Bueno-de-Mesquita HB;Quirós JR;Agudo A;Sánchez MJ;Huerta JM;Ardanaz E;Arriola L;Hedblad B;Wirfält E;Sund M;Johansson M;Key TJ;Travis RC;Khaw KT;Brage S;Wareham NJ;Riboli E
通讯作者：
Riboli E