Words fail: Lesion-symptom mapping of errors of omission in post-stroke aphasia.
Words fail: Lesion-symptom mapping of errors of omission in post-stroke aphasia.
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DOI：
10.1111/jnp.12148
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发表时间：
2019-06
影响因子：
2.2
通讯作者：
Mirman D
中科院分区：
文献类型：
--
作者：
Chen Q;Middleton E;Mirman D
物体命名受损是中风后失语症的核心缺陷，可以表现为委托错误（产生错误的单词或非单词）或遗漏错误（未能尝试命名物体）。对委托错误的详细行为、计算和神经学研究在词语产生的神经认知模型的发展中发挥了关键作用。相比之下，尽管遗漏错误在失语症和其他人群中是一种普遍现象，但其神经认知基础却根本不明确。遗漏错误的普遍存在使得它们的神经认知基础对于描述个体的缺陷非常重要，理想情况下对于个性化治疗和评估治疗结果也很重要。本研究利用病变位置和委托错误之间已建立的关系来调查图片命名中的遗漏错误。使用支持向量回归病变症状映射分析了 123 名中风后失语症患者的费城命名测试的遗漏错误率。遗漏错误与左额叶和中前颞叶病变密切相关。计算模型分析进一步表明，遗漏错误与语义驱动的词汇检索受损呈正相关，而不是与语音检索受损。这些结果表明，失语症的遗漏错误主要是由于从竞争对手的单词检索和选择中的词汇语义缺陷引起的。
Impaired object naming is a core deficit in post-stroke aphasia, which can manifest as errors of commission – producing an incorrect word or a nonword – or as errors of omission – failing to attempt to name the object. Detailed behavioral, computational, and neurological investigations of errors of commission have played a key role in development of neurocognitive models of word production. In contrast, the neurocognitive basis of omission errors is radically underspecified despite being a prevalent phenomenon in aphasia and other populations. The prevalence of omission errors makes their neurocognitive basis important for characterizing an individual’s deficits and, ideally, for personalizing treatment and evaluating treatment outcomes. The present study leveraged established relationships between lesion location and errors of commission to investigate omission errors in picture naming. Omission error rates from the Philadelphia Naming Test for 123 individuals with post-stroke aphasia were analyzed using support vector regression lesion-symptom mapping. Omission errors were most strongly associated with left frontal and mid-anterior temporal lobe lesions. Computational model analysis further showed that omission errors were positively associated with impaired semantically-driven lexical retrieval rather than phonological retrieval. These results suggest that errors of omission in aphasia predominantly arise from lexical-semantic deficits in word retrieval and selection from a competitor set.
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影响因子：
3.2
作者：
Mirman D;Graziano KM
通讯作者：
Graziano KM
影响因子：
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