Three dimensional cancellous bone structure in hypoparathyroidism.
Three dimensional cancellous bone structure in hypoparathyroidism.
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DOI：
10.1016/j.bone.2009.09.020
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发表时间：
2010-01
期刊：
影响因子：
4.1
通讯作者：
Mueller, Ralph
中科院分区：
文献类型：
--
作者：
Rubin, Mishaela R.;Dempster, David W.;Kohler, Thomas;Stauber, Martin;Zhou, Hua;Shane, Elizabeth;Nickolas, Thomas;Stein, Emily;Sliney, James, Jr.;Silverberg, Shonni J.;Bilezikian, John P.;Mueller, Ralph
通过传统的二维组织形态计量学分析，我们发现甲状旁腺功能减退症患者松质骨结构发生了显著改变。我们现在已经将这些观察结果扩展到使用微计算机断层扫描的三维分析。通过高分辨率显微计算机断层扫描分析了以下25例甲状旁腺功能减退受试者的经皮髂嵴骨活检：5例绝经后女性，13例绝经前女性和7例男性。13例绝经前健康对照和12例无骨病的尸体受试者作为匹配对照。甲状旁腺功能减退的受试者的骨表面密度显着更大（BS/TV：5.74 ± 4.7 vs. 3.73 ± 1.01 mm 2/mm 3 [平均值± SD]; p=0.04），小梁厚度（Tb.Th：0.25 ± 0.19 vs. 0.17 ± 0.04 mm; p=0.04），小梁数量（Tb.N：2.99 ± 3.4 vs. 1.62 ± 0.39 mm−1; p=0.05）和连接密度（Conn.D：16.63 ± 18.7 vs. 8.39 ± 5.8 mm 3; p=0.04）。当另外8例甲状旁腺功能减退（总计n= 33）和24具尸体（总尸体n= 36）受试者被添加到组中进行不匹配分析，甲状旁腺功能减退受试者的松质骨体积显著更大（BV/TV：26.98 ± 10 vs. 15.39 ± 4%; p< 0.001），而小梁分离（Tb.Sp：0.642 ± 0.10 vs. 0.781 ± 0.13 mm; p<0.001）和板-杆特征的估计（SMI：−0.457 ± 1.52 vs. 0.742 ± 0.51; p<0.001）显著降低，后一观察结果表明板状小梁结构更明显。甲状旁腺功能减退受试者的松质骨结构变量，通过显微计算机断层扫描评估，与传统的组织形态学评估高度相关。我们的结论是，松质骨甲状旁腺功能减退症是异常的，这表明甲状旁腺激素是必要的，以维持正常的小梁结构。这些结构变化对骨强度的影响仍有待确定。
By conventional 2-dimensional histomorphometric analysis, we have shown that cancellous bone architecture is markedly altered in hypoparathyroidism. We have now extended these observations to a 3-dimensional analysis using microcomputed tomography. Percutaneous iliac crest bone biopsies were analyzed by high-resolution microcomputed tomography from the following 25 subjects with hypoparathyroidism: 5 postmenopausal women, 13 premenopausal women and 7 men. Thirteen living premenopausal healthy controls and 12 cadaver subjects without bone disease served as matched controls. Hypoparathyroid subjects had significantly greater bone surface density (BS/TV: 5.74 ± 4.7 vs. 3.73 ± 1.01 mm2/mm3 [mean ± SD]; p=0.04), trabecular thickness (Tb.Th: 0.25 ± 0.19 vs. 0.17 ± 0.04 mm; p=0.04), trabecular number (Tb.N: 2.99 ± 3.4 vs. 1.62 ± 0.39 mm−1; p=0.05) and connectivity density (Conn.D: 16.63 ± 18.7 vs. 8.39 ± 5.8 mm3; p=0.04) in comparison to matched controls. When an additional 8 hypoparathyorid (total n= 33) and 24 cadaver (total cadaver n= 36) subjects were added to the groups for an unmatched analysis, hypoparathyroid subjects had significantly greater cancellous bone volume (BV/TV: 26.98 ± 10 vs. 15.39 ± 4%; p< 0.001), , while trabecular separation (Tb.Sp: 0.642 ± 0.10 vs. 0.781 ± 0.13 mm; p<0.001) and estimation of the plate-rod characteristic (SMI: −0.457 ± 1.52 vs. 0.742 ± 0.51; p<0.001) were significantly lower, the latter observation implying a more plate-like trabecular structure. Variables of cancellous bone structure in the hypoparathyroid subjects, as assessed by microcomputed tomography, were highly correlated with those assessed by conventional histomorphometry. We conclude that cancellous bone in hypoparathyroidism is abnormal, suggesting that parathyroid hormone is required to maintain normal trabecular structure. The effect of these structural changes on bone strength remains to be determined.
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影响因子：
6.2
作者：
Orwoll, Eric S.;Marshall, Lynn M.;Keaveny, Tony M.
通讯作者：
Keaveny, Tony M.
影响因子：
5.8
作者：
Kurland, ES;Rosen, CJ;Bilezikian, JP
通讯作者：
Bilezikian, JP
影响因子：
6.2
作者：
Hildebrand, T;Laib, A;Rüegsegger, P
通讯作者：
Rüegsegger, P
影响因子：
4.1
作者：
Müller, R;Van Campenhout, H;Rüegsegger, P
通讯作者：
Rüegsegger, P
影响因子：
4.2
作者：
Ruegsegger, P;Koller, B;Muller, R
通讯作者：
Muller, R