Nasal cytokines as mediators of illness during the common cold.

Nasal cytokines as mediators of illness during the common cold.
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鼻细胞因子作为普通感冒期间的疾病介质。

DOI:
10.1007/s11882-005-0034-8
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发表时间:
2005-05
影响因子:
5.5
通讯作者:
Gentile D
Gentile D
中科院分区:
医学2区
文献类型:
--
作者:
Doyle WJ;Skoner DP;Gentile D

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鉴定普通感冒的靶向介体是一个理想的,但迄今为止,目前的研究难以实现的目标。各种介质的作用,如组胺,白三烯,缓激肽,以及最近,趋化因子和细胞因子,在普通感冒的病理生理学和并发症的发展是以前和目前的调查的主题。由于许多原因,建立普通感冒中介质的因果关系一直很困难,包括我们研究工具和方案的局限性以及参与普通感冒的炎症和免疫途径的复杂性。现有的证据调解普通感冒是这个手稿的主题。
Identification of a pharmacologically targeted mediator of the common cold is a desirable, but, to date, elusive goal of current research. The roles of various mediators, such as histamine, leukotrienes, bradykinin, and, more recently, chemokines and cytokines, in the pathophysiology and development of complications of the common cold are the subject of previous and current investigations. Establishing causality of a mediator in the common cold has been difficult for a number of reasons, including the limitations of our research tools and protocols and the complexity of the inflammatory and immune pathways that participate during the common cold. The available evidence for mediation of the common cold is the subject of this manuscript.
DOI: 10.1016/0091-6749(94)90076-0
发表时间: 1994-07-01
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