Association of galanin and major depressive disorder in the Chinese Han population.
Association of galanin and major depressive disorder in the Chinese Han population.
复制标题
甘丙肽与中国汉族人群重度抑郁症的关系
DOI：
10.1371/journal.pone.0064617
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wang CY
中科院分区：
文献类型：
--
作者：
Wang YJ;Li H;Yang YT;Tie CL;Li F;Xu ZQ;Wang CY
本研究旨在探讨甘丙肽（galanin，GAL）基因与中国汉族人群抑郁症发病的关系。本研究共纳入符合精神障碍诊断与统计手册第四版（DSM-IV）诊断标准的抑郁症患者700例，并与673名健康对照者进行比较。在GAL基因中的10个选择的单核苷酸多态性（SNP）位点上进行连接酶检测反应。采用一系列统计学方法探讨GAL基因SNP与抑郁症易感性的相关性。GAL基因中rs694066的SNP与MDD呈正相关。与健康对照组相比，MDD患者rs694066基因G/G基因型频率较低，A/G基因型频率较高; rs694066基因G等位基因频率较低，A等位基因频率较高。这些相关性在376名女性患者和360名女性对照受试者中比在324名男性患者和313名健康男性受试者中更明显。本研究旨在探讨GAL基因SNP与中国汉族人群抑郁症易感性的关系。研究结果清楚地表明，GAL基因多态性与中国汉族女性抑郁症的发病率密切相关。
This study aimed to investigate the association of galanin (GAL) gene and the development of depression in the Chinese Han population. A total of 700 patients with depression who met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and 673 healthy controls were used in this study. Ligase detection reactions were performed on 10 selected single nucleotide polymorphism (SNP) sites in the GAL gene. A series of statistical methods were carried out to investigate the correlation between the GAL gene SNP and the patient susceptibility to depression. The SNPs of rs694066 in the GAL gene showed a positive correlation with MDD. Compared with the healthy controls, lower frequency of G/G genotype and higher frequency of A/G genotype were observed in rs694066 in MDD patients, a lower frequency of G-allele and higher frequency of A-allele were observed in rs694066. These correlations were more pronounced in the 376 female patients and 360 female control subjects than in the 324 male patients and 313 healthy male subjects. This study investigated the relationship between the GAL gene SNP and the susceptibility to depression in the Chinese Han population. The findings clearly indicate that the GAL gene polymorphism is closely correlated to the incidence of depression in the Chinese Han female patients.
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影响因子：
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作者：
Yoshitake, T;Reenilä, K;Kehr, J
通讯作者：
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影响因子：
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作者：
Kendler, KS;Sheth, K;Prescott, CA
通讯作者：
Prescott, CA
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作者：
Kendler, KS;Prescott, CA
通讯作者：
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作者：
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通讯作者：
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