Embryonic cerebrospinal fluid in brain development: neural progenitor control.
Embryonic cerebrospinal fluid in brain development: neural progenitor control.
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DOI：
10.3325/cmj.2014.55.299
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发表时间：
2014-08-28
影响因子：
1.9
通讯作者：
Desmond ME
中科院分区：
文献类型：
--
作者：
Gato A;Alonso MI;Martín C;Carnicero E;Moro JA;De la Mano A;Fernández JM;Lamus F;Desmond ME
由于世界各地几个研究小组的努力，今天我们对脑腔中包含的液体、其组成和生物学作用有了坚实的知识基础。虽然从生理学的角度来看，脑脊液是中枢神经系统中最重要的部分之一，但它似乎不是一个永久和稳定的实体，因为它的组成和生物学特性在整个生命过程中都在进化。因此，我们可以谈论脊椎动物生命周期中不同的CSF。在这篇综述中，我们集中在一个有趣的时期，脊椎动物在脉络丛形成之前发育的脑脊液。这种特定的实体被称为“胚胎脑脊液”。根据脑脊液的结构、脑脊液成分、来源和循环及其与神经上皮前体细胞(靶细胞)的相互作用，我们可以得出结论：胚胎脑脊液不同于发育后期的脑脊液，也不同于成人脑脊液。这篇文章提出了支持胚胎脑脊液奇异性的论点，主要集中在它对发育期间和成年生活中神经前体行为的影响。
Due to the effort of several research teams across the world, today we have a solid base of knowledge on the liquid contained in the brain cavities, its composition, and biological roles. Although the cerebrospinal fluid (CSF) is among the most relevant parts of the central nervous system from the physiological point of view, it seems that it is not a permanent and stable entity because its composition and biological properties evolve across life. So, we can talk about different CSFs during the vertebrate life span. In this review, we focus on the CSF in an interesting period, early in vertebrate development before the formation of the choroid plexus. This specific entity is called “embryonic CSF.” Based on the structure of the compartment, CSF composition, origin and circulation, and its interaction with neuroepithelial precursor cells (the target cells) we can conclude that embryonic CSF is different from the CSF in later developmental stages and from the adult CSF. This article presents arguments that support the singularity of the embryonic CSF, mainly focusing on its influence on neural precursor behavior during development and in adult life.
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