Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis.
Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis.
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DOI：
10.3748/wjg.v23.i33.6016
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发表时间：
2017-09-07
影响因子：
4.3
通讯作者：
Kharbanda KK
中科院分区：
文献类型：
--
作者：
Eichele DD;Kharbanda KK
炎症性肠病（IBD），包括克罗恩病和溃疡性结肠炎，是由胃肠道慢性免疫反应失调引起的复杂疾病。确切的病因尚不完全清楚，但人们普遍认为，当遗传易感宿主因刺激环境因素而发生不适当的侵袭性炎症反应时，就会发生这种情况。为了研究人类IBD的发病机制和病因学，人们开发了各种IBD动物模型，这些模型为过去几十年来的组织病理学和形态学变化以及与IBD发病机制相关的因素和治疗方案的评估提供了不可或缺的见解。最广泛使用的实验模型采用葡聚糖硫酸钠（DSS）来诱导上皮损伤。 IBD研究中的DSS结肠炎模型由于其快速、简单、重现性和可控性而优于其他各种化学诱导的实验模型。在这篇手稿中，我们回顾了小鼠结肠炎模型的最新公开研究进展，重点关注肠道屏障功能的破坏、粘蛋白对结肠炎发展的影响、微生物平衡的改变以及代谢组的变化，特别是在 DSS 结肠炎小鼠模型中及其与 IBD 发病机制的关系。
Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are complex diseases that result from the chronic dysregulated immune response in the gastrointestinal tract. The exact etiology is not fully understood, but it is accepted that it occurs when an inappropriate aggressive inflammatory response in a genetically susceptible host due to inciting environmental factors occurs. To investigate the pathogenesis and etiology of human IBD, various animal models of IBD have been developed that provided indispensable insights into the histopathological and morphological changes as well as factors associated with the pathogenesis of IBD and evaluation of therapeutic options in the last few decades. The most widely used experimental model employs dextran sodium sulfate (DSS) to induce epithelial damage. The DSS colitis model in IBD research has advantages over other various chemically induced experimental models due to its rapidity, simplicity, reproducibility and controllability. In this manuscript, we review the newer publicized advances of research in murine colitis models that focus upon the disruption of the barrier function of the intestine, effects of mucin on the development of colitis, alterations found in microbial balance and resultant changes in the metabolome specifically in the DSS colitis murine model and its relation to the pathogenesis of IBD.
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影响因子：
3.7
作者：
Cipriani S;Mencarelli A;Chini MG;Distrutti E;Renga B;Bifulco G;Baldelli F;Donini A;Fiorucci S
通讯作者：
Fiorucci S
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
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影响因子：
3.2
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通讯作者：
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24.5
作者：
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通讯作者：
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影响因子：
3.1
作者：
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通讯作者：
Caprilli, R