Is it all in the family? The effects of early social structure on neural-behavioral systems of prairie voles (Microtus ochrogaster).
Is it all in the family? The effects of early social structure on neural-behavioral systems of prairie voles (Microtus ochrogaster).
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DOI：
10.1016/j.neuroscience.2012.04.063
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发表时间：
2012-08-02
期刊：
影响因子：
3.3
通讯作者：
Trainor, B. C.
中科院分区：
文献类型：
--
作者：
Greenberg, G. D.;van Westerhuyzen, J. A.;Bales, K. L.;Trainor, B. C.
在许多物种中，向父母的过渡通常与焦虑或焦虑样行为的减少有关。在一些物种中，幼崽为年幼的兄弟姐妹提供补充的父母照顾，这种行为被称为异代育儿。尽管异源养育行为的适应性后果一直是进化研究的焦点，但对异源养育行为如何影响情感状态的了解却很少。在社会一夫一妻制的草原田鼠（Microtus ochrogaster）中，大多数幼鼠表现出异源养育行为，使该物种成为研究异源养育对未来行为结果影响的理想模型。我们将幼年田鼠随机分为同种抚养（AL）组和无同种抚养（NoAL）组，并通过升高加迷宫（EPM）、开放场测试（OFT）、惊吓箱、社会互动测试、幼崽归属测试和伴侣偏好测试对它们的焦虑和社交行为进行行为表型分析。AL田鼠比NoAL田鼠表现出更多的焦虑样行为和更少的探索行为，在EPM的张开双臂和开放场地的中心花费的时间显着减少。我们从行为表现型田鼠和未测试的兄弟姐妹的大脑中解剖了海马的CA1区域和终纹床核。在其他啮齿动物中，CA1中BDNF表达的降低通常与焦虑样行为的增加有关，而BDNF在BNST中的焦虑性作用则不太确定。Western blot分析显示，同种异体抚养增加了未试田鼠尾纹床核（bed nucleus of stria terminalis， BNST）脑源性神经营养因子（brain derived neurotrophic factor， BDNF）的表达，但降低了海马CA1区（CA1） BDNF的表达。行为表型田鼠的BNST BDNF也存在类似的差异，该区域内的BDNF水平与探索行为（即在OFT中心的时间）呈负相关。我们的研究结果表明，BDNF信号在BNST和CA1中随异源亲代经历的变化而波动，这有助于一个日益复杂的“BDNF假说”，该假说认为该分子的行为影响是区域特异性的。
The transition to parenthood is generally associated with a reduction in anxiety or anxiety-like behavior across a wide range of species. In some species, juveniles provide supplementary parental care for younger siblings, a behavior known as alloparenting. Although the fitness consequences of alloparenting behavior have been a focus of evolutionary research, less is known about how alloparenting behavior impacts affective states. In the socially monogamous prairie vole (Microtus ochrogaster), most juveniles exhibit alloparenting behavior, making the species an ideal model for examining the effects of alloparenting on future behavioral outcomes. We randomly assigned juvenile voles to alloparenting (AL) or no alloparenting (NoAL) groups and behaviorally phenotyped them for anxiety-like and social behaviors using the elevated plus maze (EPM), open field test (OFT), startle box, social interaction test, juvenile affiliation test, and partner preference test. AL voles displayed more anxiety-like and less exploratory behavior than NoAL voles, spending significantly less time in the open arms of the EPM and center of an open field. We dissected the CA1 region of the hippocampus and the bed nucleus of the stria terminalis (BNST) from brains of behaviorally phenotyped voles and nontested siblings as well. Decreased BDNF expression in CA1 has generally been associated with increased anxiety-like behavior in other rodents, while an anxiogenic role for BDNF in BNST is less established. Western blot analyses showed that alloparenting experience increased expression of brain derived neurotrophic factor (BDNF) in the bed nucleus of stria terminalis (BNST) but decreased BDNF expression in the CA1 region of hippocampus (CA1) of nontested voles. There were similar differences in BNST BDNF of behaviorally phenotyped voles, and BDNF levels within this region were negatively correlated with exploratory behavior (i.e. time in center of OFT). Our results suggest that BDNF signaling in BNST and CA1 fluctuate with alloparenting experience, and they contribute to an increasingly complex “BDNF hypothesis” in which behavioral effects of this molecule are region-specific.
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在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.2
作者：
Branchi, I;D'Andrea, I;Alleva, E
通讯作者：
Alleva, E
DOI：
10.1073/pnas.93.4.1619
发表时间：
1996-02-20
影响因子：
11.1
作者：
Coplan, JD;Andrews, MW;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
56.9
作者：
Caspi, A;McClay, J;Poulton, R
通讯作者：
Poulton, R
DOI：
10.1073/pnas.0403763101
发表时间：
2004-08-17
影响因子：
11.1
作者：
Barr, CS;Newman, TK;Higley, JD
通讯作者：
Higley, JD