Pathology related to chronic arsenic exposure.
Pathology related to chronic arsenic exposure.
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DOI：
10.1289/ehp.02110s5883
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发表时间：
2002-10
影响因子：
10.4
通讯作者：
Ladich ER
中科院分区：
文献类型：
--
作者：
Centeno JA;Mullick FG;Martinez L;Page NP;Gibb H;Longfellow D;Thompson C;Ladich ER
数百万人现在遭受与环境砷暴露有关的慢性砷中毒的影响。砷引起的毒性，特别是慢性影响，包括癌症的生物学机制还不是很清楚。美国武装部队病理学研究所（AFIP）正在参与一项国际研究工作，通过开发慢性砷中毒国际组织和肿瘤储存库（ITTRCA）来提高这一认识。ITTRCA获取，存档，并提供用于研究目的，从受试者接触砷的组织。我们在这里提供了一个简短的概述砷引起的病理，简要描述砷引起的皮肤和肝脏病变，并提出了五个案例报告，从ITTRCA。砷引起的皮肤病理学包括角化过度、色素沉着改变、Bowen病、鳞状细胞癌和基底细胞癌。一种独特的皮肤损害谱，称为砷角化病，是慢性砷中毒的特征。鲍恩病，或皮肤原位鳞状细胞癌，已被充分证明是砷暴露的结果。慢性砷中毒也可引起一系列肝脏病变。其中，肝细胞癌、血管肉瘤、肝硬化和肝门静脉硬化与砷暴露有关。我们目前的病例报告，涉及这些健康状况，即鳞状细胞癌，基底细胞癌，鲍恩病的皮肤和肝细胞癌和血管肉瘤的肝脏。四名患者曾接受含砷药物治疗哮喘、牛皮癣和梅毒等疾病，一例发生在一名长期暴露于饮用水中的砷的男孩身上。
Millions now suffer the effects of chronic arseniasis related to environmental arsenic exposure. The biological mechanisms responsible for arsenic-induced toxicity and especially chronic effects, including cancer, are not well known. The U.S. Armed Forces Institute of Pathology (AFIP) is participating in an international research effort to improve this understanding by the development of the International Tissue and Tumor Repository for Chronic Arsenosis (ITTRCA). The ITTRCA obtains, archives, and makes available for research purposes, tissues from subjects exposed to arsenic. We provide here a short overview of arsenic-induced pathology, briefly describe arsenic-induced lesions in the skin and liver, and present five case reports from the ITTRCA. Arsenic-induced skin pathology includes hyperkeratosis, pigmentation changes, Bowen disease, squamous cell carcinoma, and basal cell carcinomas. A unique spectrum of skin lesions, known as arsenical keratosis, is rather characteristic of chronic arseniasis. Bowen disease, or squamous cell carcinoma in situ of the skin, has been well documented as a consequence of arsenical exposure. A spectrum of liver lesions has also been attributed to chronic arseniasis. Of these, hepatocellular carcinoma, angiosarcoma, cirrhosis, and hepatoportal sclerosis have been associated with arsenic exposure. We present case reports that relate to these health conditions, namely, squamous cell carcinoma, basal cell carcinoma, and Bowen disease of the skin and hepatocellular carcinoma and angiosarcoma of the liver. Four patients had been treated with arsenical medications for such conditions as asthma, psoriasis, and syphilis, and one case occurred in a boy chronically exposed to arsenic in drinking water.
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影响因子：
2.9
作者：
Dueñas, C;Pérez-Alvarez, JC;López-Morante, A
通讯作者：
López-Morante, A
影响因子：
2.4
作者：
Maloney, ME
通讯作者：
Maloney, ME
影响因子：
8.3
作者：
CHEN, CJ;HSUEH, YM;TAI, TY
通讯作者：
TAI, TY
影响因子：
3.5
作者：
Falk, H;Caldwell, G G;Popper, H
通讯作者：
Popper, H
影响因子：
8.7
作者：
Chen, CJ;Chiou, HY;Tai, TY
通讯作者：
Tai, TY