Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage.
Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage.
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DOI：
10.1016/j.vaccine.2018.02.016
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发表时间：
2018-03-27
期刊：
影响因子：
5.5
通讯作者：
King DP
中科院分区：
文献类型：
--
作者：
Waters R;Ludi AB;Fowler VL;Wilsden G;Browning C;Gubbins S;Statham B;Bin-Tarif A;Mioulet V;King DJ;Colenutt C;Brown E;Hudelet P;King DP
FMDV A/ASIA/G-VII 谱系最近已传播到印度次大陆以外的地区。研究评估了高效多价疫苗在牛身上的性能。应开发针对 A/ASIA/G-VII 谱系的新疫苗株。 2015年，中东爆发的口蹄疫（FMD）被发现是由最近从印度次大陆出现的病毒谱系（A/ASIA/G-VII）引起的。世界参考实验室 (WRLFMD) 生成的体外疫苗匹配数据表明，A/ASIA/G-VII 野病毒与该地区已使用的疫苗（A-SAU-95、A22 IRQ 和 A-IRN-05）匹配不佳。为了评估其中一种市售 FMD 疫苗的可能性能，对 16 头牛接种了多价疫苗，该疫苗含有两种 A 血清型成分（A-SAU-95 和 A-IRN-05），同源效力至少为 6PD50，另外 2 头牛未接种作为对照。 21 天后，所有 18 头牛都接受了来自 A/ASIA/G-VII 谱系的 FMDV 现场分离株 A/IRN/22/2015 的舌头接种攻击，符合欧洲药典 PPG 测试条件。两只对照动物出现了全身性 FMD，7/16 接种疫苗的动物出现了至少一只足部病变，因此只有 56.3% 被定义为受保护。对于疫苗成分，随着 A-SAU-95 血清学滴度的增加，保护概率显着增加 (p=0.03)，但 A-IRN-05 则没有 (p=0.42)。对血液和鼻拭子中口蹄疫病毒的分析表明，即使动物出现足部病变，疫苗接种也能减少口蹄疫病毒的脱落和潜在的进一步传播。总之，这项研究的结果表明，虽然这种疫苗不适合在紧急情况下使用（在以前无口蹄疫的国家），但在实行重复预防性疫苗接种的流行国家，它可能部分有效。对于紧急反应性疫苗接种，这项研究的结果支持了这样的想法：应开发针对 A/ASIA/G-VII 谱系的新疫苗株。
FMDV A/ASIA/G-VII lineage has recently spread beyond the Indian sub-continent. Study evaluated the performance of a high potency polyvalent vaccine in cattle. A new vaccine strain should be developed which is tailored to the A/ASIA/G-VII lineage. In 2015, outbreaks of foot-and-mouth disease (FMD) in the Middle East were discovered to be caused by a viral lineage (A/ASIA/G-VII), which has recently emerged from the Indian sub-continent. In vitro vaccine matching data generated by the World Reference Laboratory (WRLFMD) indicated that A/ASIA/G-VII field viruses were poorly matched with vaccines (A-SAU-95, A22 IRQ and A-IRN-05) that are already used in the region. In order to assess the likely performance of one of these commercially available FMD vaccines, sixteen cattle were vaccinated with a polyvalent vaccine which contained two serotype A components (A-SAU-95 and A-IRN-05) with a homologous potency of at least 6PD50, and two cattle were left unvaccinated as controls. Twenty-one days later, all 18 cattle were challenged by tongue inoculation with an FMDV field isolate A/IRN/22/2015 from the A/ASIA/G-VII lineage, in line with the European Pharmacopeia PPG test conditions. The two control animals developed generalised FMD, and 7/16 vaccinated animals developed at least one foot lesion, thus only 56.3% were defined as protected. For the vaccine components, there was a significant increase in the probability of protection with increasing serological titres for A-SAU-95 (p = 0.03), but not for A-IRN-05 (p = 0.42). Analysis of FMDV in blood and nasal swabs suggested that vaccination reduced shedding and potential onward spread of FMD virus even if the animal developed foot lesions. In summary, the results from this study suggest that whilst this vaccine would not be appropriate for use in an emergency situation (in previously FMD-free countries), it may be partially effective in the field in endemic countries where repeat prophylactic vaccination is practiced. For emergency reactive vaccination, the findings from this study support the idea that a new vaccine strain should be developed that is tailored to the A/ASIA/G-VII lineage.
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DOI：
10.1126/science.1199884
发表时间：
2011-05-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Charleston B;Bankowski BM;Gubbins S;Chase-Topping ME;Schley D;Howey R;Barnett PV;Gibson D;Juleff ND;Woolhouse ME
通讯作者：
Woolhouse ME
DOI：
10.1016/j.tvjl.2007.12.031
发表时间：
2008-04
期刊：
Veterinary journal (London, England : 1997)
影响因子：
--
作者：
Sheldon IM;Williams EJ;Miller AN;Nash DM;Herath S
通讯作者：
Herath S
影响因子：
5.5
作者：
Brehm, K. E.;Kumar, N.;Haas, B.
通讯作者：
Haas, B.
影响因子：
5.5
作者：
Cox, SJ;Voyce, C;Barnett, PV
通讯作者：
Barnett, PV
DOI：
10.2460/javma.2002.220.1636
发表时间：
2002-06-01
期刊：
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
影响因子：
--
作者：
Callahan, JD;Brown, F;Nelson, WM
通讯作者：
Nelson, WM