Pesticide exposure and risk of Parkinson's disease: a family-based case-control study.
Pesticide exposure and risk of Parkinson's disease: a family-based case-control study.
复制标题
农药接触和帕金森病风险：基于家庭的病例对照研究。
DOI：
10.1186/1471-2377-8-6
复制
发表时间：
2008-03-28
期刊：
影响因子：
2.6
通讯作者：
Scott, William K.
中科院分区：
文献类型：
--
作者：
Hancock, Dana B.;Martin, Eden R.;Mayhew, Gregory M.;Stajich, Jeffrey M.;Jewett, Rita;Stacy, Mark A.;Scott, Burton L.;Vance, Jeffery M.;Scott, William K.
农药和相关的生活方式因素（例如，暴露于井水和农业）是帕金森病（PD）的危险因素，但很少有以家庭为基础的研究探讨了这些关系。使用319例和296个相对和其他控制，协会直接农药的应用，井水消耗量，和农村住宅/职业与PD进行了检查，同时控制年龄检查，性别，吸烟，咖啡因的消费，使用广义估计方程。总体而言，PD患者比其未受影响的亲属更有可能报告直接施用农药（比值比= 1.61; 95%置信区间，1.13-2.29）。频率、持续时间和累积暴露量也与剂量-反应模式中的PD显著相关（p ≤ 0.013）。直接施用农药的关联没有因性别而异，但PD家族史进行了修改，因为显着的关联仅限于没有家族史的个体。当按功能类型对农药进行分类时，发现杀虫剂和除草剂都显着增加PD的风险。两个特定的杀虫剂类，有机氯和有机磷化合物，与PD显着相关。饮用井水和在农场生活/工作与PD无关。这些数据证实了广泛定义的农药暴露与家庭PD的正相关性，特别是对于散发性PD。这些数据还涉及一些特定类别的农药在PD，因此强调需要考虑一个更窄的定义农药在未来的研究。
Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD), but few family-based studies have examined these relationships. Using 319 cases and 296 relative and other controls, associations of direct pesticide application, well-water consumption, and farming residences/occupations with PD were examined using generalized estimating equations while controlling for age-at-examination, sex, cigarette smoking, and caffeine consumption. Overall, individuals with PD were significantly more likely to report direct pesticide application than their unaffected relatives (odds ratio = 1.61; 95% confidence interval, 1.13–2.29). Frequency, duration, and cumulative exposure were also significantly associated with PD in a dose-response pattern (p ≤ 0.013). Associations of direct pesticide application did not vary by sex but were modified by family history of PD, as significant associations were restricted to individuals with no family history. When classifying pesticides by functional type, both insecticides and herbicides were found to significantly increase risk of PD. Two specific insecticide classes, organochlorines and organophosphorus compounds, were significantly associated with PD. Consuming well-water and living/working on a farm were not associated with PD. These data corroborate positive associations of broadly defined pesticide exposure with PD in families, particularly for sporadic PD. These data also implicate a few specific classes of pesticides in PD and thus emphasize the need to consider a more narrow definition of pesticides in future studies.
登录
查看更多内容
影响因子：
10.4
作者：
Brown TP;Rumsby PC;Capleton AC;Rushton L;Levy LS
通讯作者：
Levy LS
影响因子：
3
作者：
HEIKKILA, RE;SONSALLA, PK
通讯作者：
SONSALLA, PK
影响因子：
9.9
作者：
Maher, NE;Golbe, LI;Myers, RH
通讯作者：
Myers, RH
影响因子：
10.4
作者：
Kamel F;Hoppin JA
通讯作者：
Hoppin JA
影响因子：
9.9
作者：
BUTTERFIELD, PG;VALANIS, BG;NUTT, JG
通讯作者：
NUTT, JG