Marrow fat and bone: review of clinical findings.
Marrow fat and bone: review of clinical findings.
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DOI：
10.3389/fendo.2015.00040
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发表时间：
2015
影响因子：
5.2
通讯作者：
Schwartz AV
中科院分区：
文献类型：
--
作者：
Schwartz AV
随着人们对脂肪和骨骼之间的联系越来越感兴趣，特别是与骨髓脂肪之间的关系的研究也越来越多。非侵入性方法的发展促进了临床研究，以测量骨髓脂肪含量和成分。在不同人群中使用不同测量技术的研究已经证实，较高的骨髓脂肪与较低的骨密度和普遍存在的脊椎骨折有关。骨髓脂肪的不饱和程度也可能影响骨骼健康。尽管其他脂肪库往往有很强的相关性，但骨髓脂肪有不同的模式，这表明控制机制是分开的。纵向研究有限，但对于了解骨髓脂肪作为对骨骼健康的影响的直接和间接作用至关重要。随着人们对骨骼和能量代谢之间联系的进一步了解，人们对了解骨髓脂肪和骨骼之间的关系也越来越感兴趣。众所周知，患有骨质疏松症的老年人骨髓脂肪水平较高，骨质疏松症的定义是骨密度低或脊椎骨折。然而，这种联系的原因和影响尚不清楚。本文就骨髓脂肪及其与骨的关系的临床研究作一综述。
With growing interest in the connection between fat and bone, there has been increased investigation of the relationship with marrow fat in particular. Clinical research has been facilitated by the development of non-invasive methods to measure bone marrow fat content and composition. Studies in different populations using different measurement techniques have established that higher marrow fat is associated with lower bone density and prevalent vertebral fracture. The degree of unsaturation in marrow fat may also affect bone health. Although other fat depots tend to be strongly correlated, marrow fat has a distinct pattern, suggesting separate mechanisms of control. Longitudinal studies are limited, but are crucial to understand the direct and indirect roles of marrow fat as an influence on skeletal health. With greater appreciation of the links between bone and energy metabolism, there has been growing interest in understanding the relationship between marrow fat and bone. It is well established that levels of marrow fat are higher in older adults with osteoporosis, defined by either low bone density or vertebral fracture. However, the reasons for and implications of this association are not clear. This review focuses on clinical studies of marrow fat and its relationship to bone.
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DOI：
10.1359/jbmr.090805
发表时间：
2010-02
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Ecklund K;Vajapeyam S;Feldman HA;Buzney CD;Mulkern RV;Kleinman PK;Rosen CJ;Gordon CM
通讯作者：
Gordon CM
DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
DOI：
10.1046/j.1532-5415.2003.51558.x
发表时间：
2003-12-01
影响因子：
6.3
作者：
Ensrud, KE;Ewing, SK;Cummings, SR
通讯作者：
Cummings, SR
影响因子：
5.8
作者：
Arasu, Aarthi;Cawthon, Peggy M.;Cummings, Steven R.
通讯作者：
Cummings, Steven R.
影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna