Simultaneous PET-MRI in oncology: a solution looking for a problem?
Simultaneous PET-MRI in oncology: a solution looking for a problem?
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DOI：
10.1016/j.mri.2012.06.001
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发表时间：
2012-11
影响因子：
2.5
通讯作者：
Gore, John C.
中科院分区：
文献类型：
--
作者：
Yankeelov, Thomas E.;Peterson, Todd E.;Abramson, Richard G.;Garcia-Izquierdo, David;Arlinghaus, Lori R.;Li, Xia;Atuegwu, Nkiruka C.;Catana, Ciprian;Manning, H. Charles;Fayad, Zahi A.;Gore, John C.
随着集成正电子发射断层扫描-磁共振成像（PET-MRI）扫描仪的最新发展，实现了癌症定量分子成像的新可能性。然而，同时记录PET和MRI数据的能力的实际优势和潜在临床益处必须与此类设备的大量成本和其他要求相平衡。在这篇综述中，我们强调了几个关键领域，其中集成PET-MRI测量，同时获得，预计有一个显着的影响，临床和/或研究。这些领域包括使用基于MR的运动校正和/或先验解剖信息来改善PET数据的重建;改善PET动力学建模的动脉输入功能表征;使用双模态造影剂;以及患者舒适度和实用便利性。为了得到广泛接受，如果定量MRI和特定PET生物标志物的组合显着提高了我们评估肿瘤状态和治疗反应的能力，并且现在出现了一些可能的候选人，那么就可以提出令人信服的案例。我们认为PET-MRI提供的相对优势和劣势，并总结目前的意见和证据，PET-MRI在癌症的管理可能的价值。
With the recent development of integrated positron emission tomography-magnetic resonance imaging (PET-MRI) scanners, new possibilities for quantitative molecular imaging of cancer are realized. However, the practical advantages and potential clinical benefits of the ability to record PET and MRI data simultaneously must be balanced against the substantial costs and other requirements of such devices. In this review we highlight several of the key areas where integrated PET-MRI measurements, obtained simultaneously, are anticipated to have a significant impact on clinical and/or research studies. These areas include the use of MR-based motion corrections and/or a priori anatomical information for improved reconstruction of PET data; improved arterial input function characterization for PET kinetic modeling; the use of dual-modality contrast agents; and patient comfort and practical convenience. For widespread acceptance, a compelling case could be made if the combination of quantitative MRI and specific PET biomarkers significantly improves our ability to assess tumor status and response to therapy, and some likely candidates are now emerging. We consider the relative advantages and disadvantages afforded by PET-MRI and summarize current opinions and evidence as to the likely value of PET-MRI in the management of cancer.
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影响因子：
16.6
作者：
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