Variability of trabecular microstructure is age-, gender-, race- and anatomic site-dependent and affects stiffness and stress distribution properties of human vertebral cancellous bone.
Variability of trabecular microstructure is age-, gender-, race- and anatomic site-dependent and affects stiffness and stress distribution properties of human vertebral cancellous bone.
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DOI：
10.1016/j.bone.2011.07.006
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发表时间：
2011-10
期刊：
影响因子：
4.1
通讯作者：
Fyhrie, David P.
中科院分区：
文献类型：
--
作者：
Yeni, Yener N.;Zinno, Matthew J.;Yerramshetty, Janardhan S.;Zauel, Roger;Fyhrie, David P.
松质骨微观结构是椎骨机械完整性的重要决定因素。已广泛研究的众多微观结构参数通常表示为作为样品平均值获得的单个值。松质微结构的样本内变异范围及其对骨机械性能的影响尚不清楚。本研究的目的是调查椎骨内的人类松质骨微结构 i) 与骨模量和应力分布特性的相关程度，以及 ii) 随年龄、性别和位置胸椎 12 (T12) 与腰椎 1 (L1) 的变化。从 15 具男性（66±15 岁）和 25 具女性（54±16 岁）尸体中采集椎骨。使用圆柱形样本的微计算机断层扫描图像构建了三维有限元模型。线性有限元模型用于估计单轴压缩过程中气缸的表观模量和应力。计算微观结构变量的样本内平均值、标准差（SD）和变异系数（CV）。结果的混合模型统计分析表明，样本内微观结构变异性的增加导致小梁应力变异性的增加和骨刚度的降低。这些影响与微观结构的样本内平均值的贡献无关。此外，连通性和各向异性并未解释微观结构变异对骨刚度和应力变异的影响。微观结构变异性（SD、CV）通常随着年龄的增长而增加，女性大于男性，T12 大于 L1。年龄、性别、椎骨和种族之间发现了显着的相互作用。这些相互作用表明，微观结构变异特性随年龄的变化在性别、种族和椎骨水平之间有所不同。目前的结果共同表明，微观结构变异对人类椎体松质骨的机械性能和组织应力有显着影响。考虑微观结构的变异性可以提高对骨脆性的理解并改善椎骨骨折风险的评估。
Cancellous bone microstructure is an important determinant of the mechanical integrity of vertebrae. The numerous microstructural parameters that have been studied extensively are generally represented as a single value obtained as an average over a sample. The range of the intra-sample variability of cancellous microstructure and its effect on the mechanical properties of bone are less well-understood. The objectives of this study were to investigate the extent to which human cancellous bone microstructure within a vertebra i) is related to bone modulus and stress distribution properties and ii) changes along with age, gender and locations thoracic 12 (T12) vs lumbar 1 (L1). Vertebrae were collected from 15 male (66±15 yrs) and 25 female (54±16 yrs) cadavers. Three dimensional finite element models were constructed using microcomputed tomography images of cylindrical specimens. Linear finite element models were used to estimate apparent modulus and stress in the cylinders during uniaxial compression. The intra-specimen mean, standard deviation (SD) and coefficient of variation (CV) of microstructural variables were calculated. Mixed model statistical analysis of the results demonstrated that increases in the intra-specimen variability of the microstructure contribute to increases in the variability of trabecular stresses and decreases in bone stiffness. These effects were independent from the contribution from intra-specimen average of the microstructure. Further, the effects of microstructural variability on bone stiffness and stress variability were not accounted for by connectivity and anisotropy. Microstructural variability properties (SD, CV) generally increased with age, were greater in females than in males and in T12 than in L1. Significant interactions were found between age, gender, vertebra and race. These interactions suggest that microstructural variability properties varied with age differently between genders, races and vertebral levels. The current results collectively demonstrate that microstructural variability has a significant effect on mechanical properties and tissue stress of human vertebral cancellous bone. Considering microstructural variability could improve the understanding of bone fragility and improve assessment of vertebral fracture risk.
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影响因子：
3.8
作者：
Kim, Do-Gyoon;Hunt, Christine A.;Yeni, Yener N.
通讯作者：
Yeni, Yener N.
影响因子：
6.2
作者：
Han, ZH;Palnitkar, S;Parfitt, AM
通讯作者：
Parfitt, AM
影响因子：
4.1
作者：
Eckstein, F;Fischbeck, M;Lochmüller, EM
通讯作者：
Lochmüller, EM
影响因子：
2.4
作者：
Hou, FJ;Lang, SM;Fyhrie, DP
通讯作者：
Fyhrie, DP
影响因子：
2.4
作者：
GOULET, RW;GOLDSTEIN, SA;FELDKAMP, LA
通讯作者：
FELDKAMP, LA