The distributed circuit within the piriform cortex makes odor discrimination robust
The distributed circuit within the piriform cortex makes odor discrimination robust
复制标题
梨状皮层内的分布式电路使气味辨别能力更强
DOI：
10.1002/cne.24492
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发表时间：
2018
影响因子：
2.5
通讯作者：
C. Stevens
中科院分区：
文献类型：
--
作者：
Shyam Srinivasan;C. Stevens
在嗅觉回路、海马体和小脑中，子回路之间的连接似乎是随机分布的分布式回路很常见。在这样的回路中，激活模式似乎也是随机的，没有显示出可检测的空间偏好，并与子回路和地形激活模式之间具有地形连接的区域形成对比。对新皮层地形回路的定量研究已经得出了组织的共同原则。分布式电路是否具有类似的组织原则尚不清楚，因为缺少类似的定量信息，理解它们编码信息的方式仍然是一个挑战。我们通过对小鼠梨状皮质的定量描述来满足这些需求，梨状皮质是一种辅助嗅觉的古皮质分布回路。定量信息提供了两种见解。首先，通过一个几乎无参数的嗅觉回路模型，我们证明了梨状皮质鲁棒地维持着嗅球中存在的气味信息和辨别能力。第二，古皮质在数量上不同于新皮质：它具有较低的表面积密度，与新皮质的均匀神经元密度相比，从前部到后部古皮质的表面积密度降低。这些见解也可能适用于其他分布式电路。
Distributed circuits wherein connections between subcircuit components seem randomly distributed are common to the olfactory circuit, hippocampus, and cerebellum. In such circuits, activation patterns seem random too, showing no detectable spatial preference, and contrast with regions that have topographic connections between subcircuits and topographic activation patterns. Quantitative studies of topographic circuits in the neocortex have yielded common principles of organization. Whether distributed circuits share similar principles of organization is unknown because similar quantitative information is missing and understanding the way they encode information remains a challenge. We addressed these needs by providing a quantitative description of the mouse piriform cortex, a paleocortical distributed circuit that subserves olfaction. The quantitative information provided two insights. First, with a nearly parameter‐free model of the olfactory circuit, we show that the piriform cortex robustly maintains odor information and discrimination ability present in the olfactory bulb. Second, the paleocortex is quantitatively different from the neocortex: it has a lower surface area density, which decreases from the anterior to posterior paleocortex contrasting with the uniform neuronal density of the neocortex. These insights might also apply to other distributed circuits.
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