Protective Effects of Green Tea Extract against Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats.
Protective Effects of Green Tea Extract against Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats.
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DOI：
10.1155/2012/740671
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Nazeri M
中科院分区：
文献类型：
--
作者：
Abolfathi AA;Mohajeri D;Rezaie A;Nazeri M
虽然糖尿病肝病可能不太常见，但它可能适合添加到与糖尿病相关的靶器官疾病列表中。本研究旨在评价绿色茶提取物（GTE）对STZ诱导的糖尿病大鼠的保肝作用。Wistar大鼠腹腔注射STZ（75 mg/kg），造成糖尿病模型。大鼠随机分为四组，每组10只动物：第1组，健康对照组;第2组，非糖尿病患者口服GTE（1.5%，w/v）治疗;第3组，糖尿病患者;第4组，糖尿病患者接受GTE（1.5%，w/v）治疗8周。评估血清生物标志物以确定肝损伤。测定丙二醛（MDA）和还原型谷胱甘肽（GSH）含量，以评估肝组织中的自由基活性。测定肝脏谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的抗氧化活性。生化结果与组织病理学验证相匹配。肝组织MDA含量及血清ALT、AST、ALP、胆红素水平3组较1组显著升高（P < 0.05），4组较3组显著降低（P < 0.05）。结果表明：与对照组相比，试验3组血清白蛋白水平和肝脏GSH、SOD、CAT、GSH-Px含量显著降低（P < 0.05），试验4组血清白蛋白水平和肝脏GSH、SOD、CAT、GSH-Px含量显著升高（P < 0.05）。组织学上的变化与生化检查结果一致。本研究证实了GTE对实验性糖尿病大鼠的肝保护作用。
Although diabetic hepatopathy is potentially less common, it may be appropriate for addition to the list of target organ conditions related to diabetes. This study was designed to evaluate the hepatoprotective properties of green tea extract (GTE) in STZ-induced diabetes in rats. Wistar rats were made diabetic through single injection of STZ (75 mg/kg i.p.). The rats were randomly divided into four groups of 10 animals each: Group 1, healthy control; Group 2, nondiabetics treated with GTE administered orally (1.5%, w/v); Group 3, diabetics; Group 4, diabetics treated with GTE (1.5%, w/v) for 8 weeks. Serum biomarkers were assessed to determine hepatic injury. Malondialdehyde (MDA) and reduced glutathione (GSH) contents were measured to assess free radical activity in the liver tissue. Hepatic antioxidant activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) were also determined. The biochemical findings were matched with histopathological verifications. Liver MDA content and serum levels of ALT, AST, ALP, and bilirubin in Group 3 significantly increased compared to Group 1 (P < 0.05) and significantly decreased in Group 4 compared to Group 3 (P < 0.05). Serum albumin level and GSH, SOD, CAT, and GSH-Px contents of the liver in Group 3 were significantly decreased compared to Group 1 (P < 0.05) and were significantly increased in Group 4 compared to Group 3 (P < 0.05). Histopathologically, the changes were in the same direction with biochemical findings. This study proved the hepatoprotective activity of GTE in experimentally induced diabetic rats.
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影响因子：
4.2
作者：
Frei, B;Higdon, JV
通讯作者：
Higdon, JV
DOI：
10.1196/annals.1333.088
发表时间：
2005-01-01
期刊：
MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE
影响因子：
--
作者：
Jandeleit-Dahm, KA;Lassila, M;Allen, TJ
通讯作者：
Allen, TJ
影响因子：
4.2
作者：
Crespy, V;Williamson, G
通讯作者：
Williamson, G
影响因子：
5.9
作者：
GRIESMACHER, A;KINDHAUSER, M;MUELLER, MM
通讯作者：
MUELLER, MM
影响因子：
5
作者：
Feillet-Coudray, C;Rock, E;Mazur, A
通讯作者：
Mazur, A