XLMR candidate mouse gene, Zcchc12 (Sizn1) is a novel marker of Cajal-Retzius cells.
XLMR candidate mouse gene, Zcchc12 (Sizn1) is a novel marker of Cajal-Retzius cells.
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DOI：
10.1016/j.gep.2010.12.005
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Golden JA
中科院分区：
文献类型：
--
作者：
Cho G;Lim Y;Golden JA
Sizn 1（Zcchc 12）是一种转录共激活因子，通过与Smad家族成员和CBP的相互作用积极调节BMP（骨形态发生蛋白）信号传导。我们已经证明了Sizn 1在基底前脑胆碱能神经元特异性基因表达中的作用。此外，SIZN 1的突变与X连锁精神发育迟滞有关。鉴于SIZN 1在智力迟钝中的作用，了解其完整的前脑表达模式对于进一步阐明其在认知中的作用至关重要。为了更好地确定Sizn 1在前脑发育过程中的动态表达模式，我们研究了其在小鼠胚胎8.0天（E8.0）至成年脑发育中的表达。我们发现Sizn 1主要局限于腹侧前脑，包括内侧神经节隆起，隔膜，杏仁核和纹状体。此外，Sizn 1表达在皮质hem和Pallial-subpallial边界（PSB; anti-hem）中检测到;这两种Cajal-Retzius细胞的来源。背侧前脑中的Sizn 1表达仅限于边缘区中也表达Reln的细胞亚群，指示Cajal-Retzius细胞。这些数据为表达Sizn 1的脑区和细胞类型提供了新的信息，有助于进一步研究Sizn 1在发育和精神发育迟滞发病机制中的功能。
Sizn1 (Zcchc12) is a transcriptional co-activator that positively modulates BMP (Bone Morphogenic Protein) signaling through its interaction with Smad family members and CBP. We have demonstrated a role for Sizn1 in basal forebrain cholinergic neuron specific gene expression. Furthermore, mutations in SIZN1 have been associated with X-linked mental retardation. Given the defined role of SIZN1 in mental retardation, knowing its complete forebrain expression pattern is essential to further elucidating its role in cognition. To better define the dynamic expression pattern of Sizn1 during forebrain development, we investigated its expression in mouse brain development from embryonic day 8.0 (E8.0) to adult. We found that Sizn1 is primarily restricted to the ventral forebrain including the medial ganglionic eminence, the septum, amygdala, and striatum. In addition, Sizn1 expression is detected in the cortical hem and Pallial-subpallial boundary (PSB; anti-hem); both sources of Cajal-Retzius cells. Sizn1 expression in the dorsal forebrain is restricted to a subset of cells in the marginal zone that also express Reln, indicative of Cajal-Retzius cells. These data provide novel information on brain regions and cell types that express Sizn1, facilitating further investigations into the function of Sizn1 in both development and the pathogenesis of mental retardation.
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影响因子：
2
作者：
Cho, Ginam;Bhat, Shambhu S.;Gao, Jinsong;Collins, Julianne S.;Rogers, R. Curtis;Simensen, Richard J.;Schwartz, Charles E.;Golden, Jeffrey A.;Srivastava, Anand K.
通讯作者：
Srivastava, Anand K.
影响因子：
3.7
作者：
Li, Hong;Liu, Qian;Zhang, Jian
通讯作者：
Zhang, Jian
影响因子：
2.6
作者：
Lim, Y;Golden, JA
通讯作者：
Golden, JA
影响因子：
2.5
作者：
WOOLF, NJ;ECKENSTEIN, F;BUTCHER, LL
通讯作者：
BUTCHER, LL
影响因子：
5.3
作者：
Takiguchi-Hayashi, K;Sekiguchi, M;Tanabe, Y
通讯作者：
Tanabe, Y