Differential Trajectory of Diffusion and Perfusion Magnetic Resonance Imaging of Rat Spinal Cord Injury.
Differential Trajectory of Diffusion and Perfusion Magnetic Resonance Imaging of Rat Spinal Cord Injury.
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大鼠脊髓损伤的扩散和灌注磁共振成像的差分轨迹。
DOI：
10.1089/neu.2022.0283
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发表时间：
2023
影响因子：
4.2
通讯作者：
Budde,MatthewD
中科院分区：
文献类型：
--
作者：
Meyer,BrianaP;Lee,Seung-Yi;Kurpad,ShekarN;Budde,MatthewD
创伤性脊髓损伤导致神经元和血管快速损伤，需要预测性生物标志物来促进急性患者管理。本研究在啮齿动物模型中检查了脊髓损伤后磁共振成像（MRI）生物标志物的进展及其预测长期神经学结局的能力，重点是轴突损伤的弥散加权成像（DWI）标志物和脊髓血流灌注加权成像（SCBF）。成年Sprague-Dawley大鼠接受不同严重程度的颈部挫伤（损伤= 30，假手术= 9）。损伤后4小时、48小时和12周的MRI包括T1、T2、灌注和DWI。运动结果在受伤后12周进行评估。在4小时，SCBF的赤字大于DWI病变，虽然SCBF部分恢复到48小时，DWI病变扩大。在4小时，SCBF缺损的体积（R2= 0.56，padj< 0.01）与12周的运动结果显著相关，而DWI（R2= 0.30，padj< 0.01）对结果的预测性较低。在48 h，SCBF（R2= 0.41，padj< 0.01）与结局的相关性变小，DWI（R2= 0.38，padj< 0.01）病变体积与结局的相关性变大。脊髓灌注具有独特的时空动力学相比，轴突损伤的扩散措施，并强调急性灌注异常的重要性。灌注和扩散提供了补充和临床相关的洞察脊髓损伤后的生理和结构异常超出了T1或T2对比。
Traumatic spinal cord injury causes rapid neuronal and vascular injury, and predictive biomarkers are needed to facilitate acute patient management. This study examined the progression of magnetic resonance imaging (MRI) biomarkers after spinal cord injury and their ability to predict long-term neurological outcomes in a rodent model, with an emphasis on diffusion-weighted imaging (DWI) markers of axonal injury and perfusion-weighted imaging of spinal cord blood flow (SCBF). Adult Sprague–Dawley rats received a cervical contusion injury of varying severity (injured = 30, sham = 9). MRI at 4 h, 48-h, and 12-weeks post-injury included T1, T2, perfusion, and DWI. Locomotor outcome was assessed up to 12 weeks post-injury. At 4 h, the deficit in SCBF was larger than the DWI lesion, and although SCBF partially recovered by 48 h, the DWI lesion expanded. At 4 h, the volume of the SCBF deficit (R2= 0.56, padj< 0.01) was significantly correlated with 12-week locomotor outcome, whereas DWI (R2= 0.30, padj< 0.01) was less predictive of outcome. At 48 h, SCBF (R2= 0.41, padj< 0.01) became less associated with outcome, and DWI (R2= 0.38, padj< 0.01) lesion volume became more closely related to outcome. Spinal cord perfusion has unique spatiotemporal dynamics compared with diffusion measures of axonal damage and highlights the importance of acute perfusion abnormalities. Perfusion and diffusion offer complementary and clinically relevant insight into physiological and structural abnormalities following spinal cord injury beyond those afforded by T1or T2contrasts.
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