A neuronal mechanism controlling the choice between feeding and sexual behaviors in Drosophila.
A neuronal mechanism controlling the choice between feeding and sexual behaviors in Drosophila.
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DOI：
10.1016/j.cub.2021.07.029
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发表时间：
2021-10-11
期刊：
影响因子：
--
通讯作者：
Rezaval C
中科院分区：
文献类型：
--
作者：
Cheriyamkunnel SJ;Rose S;Jacob PF;Blackburn LA;Glasgow S;Moorse J;Winstanley M;Moynihan PJ;Waddell S;Rezaval C
动物必须表达适当的行为，以满足其最迫切的生理需求和环境背景。然而，目前尚不清楚如何评估不同的行为选择，以及如何优先考虑适当的行动。在这里，我们描述了果蝇如何在觅食和求偶之间做出选择；这是生存和繁殖所必需的两种行为。我们表明，性和食物被剥夺的雄性果蝇优先考虑进食而不是求爱，并且操纵食物质量或动物的内部状态微调了这一决定。我们确定酪胺信号通路是这一决定的重要中介。酪胺的生物合成受果蝇营养状况的调节，并作为一种饱腹感信号，倾向于求偶而不是进食。酪胺抑制了一组促食酪胺受体（TyrR）表达神经元的子集，并激活了P1神经元，这是一个已知的求爱指挥中心。相反，对营养食物来源的感知会激活TyrR神经元并抑制P1神经元。因此，饥饿通过酪胺水平和食物可得性对TyrR和P1神经元进行相反的调节。我们提出，控制替代行为的神经元的拮抗共调节是以上下文依赖的方式优先考虑竞争驱动的关键。被剥夺了食物和性的雄性果蝇有竞争的需求在觅食和交配之间的选择是由食物质量和内部驱动调节的酪胺信号介导觅食和求爱之间的选择觅食和求爱神经元之间的拮抗决定了所选择的行为大脑如何评估替代选择以及特定行为的优先顺序？Cheriyamkunnel等人描述了一种新的神经机制，果蝇通过整合营养供应和动机驱动来平衡和优先考虑喂养和交配的竞争需求。
Animals must express the appropriate behavior that meets their most pressing physiological needs and their environmental context. However, it is currently unclear how alternative behavioral options are evaluated and appropriate actions are prioritized. Here, we describe how fruit flies choose between feeding and courtship; two behaviors necessary for survival and reproduction. We show that sex- and food-deprived male flies prioritize feeding over courtship initiation, and manipulation of food quality or the animal’s internal state fine-tunes this decision. We identify the tyramine signaling pathway as an essential mediator of this decision. Tyramine biosynthesis is regulated by the fly’s nutritional state and acts as a satiety signal, favoring courtship over feeding. Tyramine inhibits a subset of feeding-promoting tyramine receptor (TyrR)-expressing neurons and activates P1 neurons, a known command center for courtship. Conversely, the perception of a nutritious food source activates TyrR neurons and inhibits P1 neurons. Therefore, TyrR and P1 neurons are oppositely modulated by starvation, via tyramine levels, and food availability. We propose that antagonistic co-regulation of neurons controlling alternative actions is key to prioritizing competing drives in a context- dependent manner. Drosophila males deprived of both food and sex have competing needs Choosing between feeding or mating is modulated by food quality and internal drive Tyramine signaling mediates the choice between feeding and courtship Antagonism between feeding and courtship neurons determines the behavior selected How are alternative options evaluated in the brain and specific actions prioritized? Cheriyamkunnel et al. describe a novel neural mechanism by which fruit flies balance and prioritize the competing needs of feeding and mating by integrating nutrient availability and motivational drives.
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影响因子：
16.2
作者：
Burnett CJ;Li C;Webber E;Tsaousidou E;Xue SY;Brüning JC;Krashes MJ
通讯作者：
Krashes MJ
影响因子：
64.5
作者：
Asahina K;Watanabe K;Duistermars BJ;Hoopfer E;González CR;Eyjólfsdóttir EA;Perona P;Anderson DJ
通讯作者：
Anderson DJ
影响因子：
4.5
作者：
Chen J;Reiher W;Hermann-Luibl C;Sellami A;Cognigni P;Kondo S;Helfrich-Förster C;Veenstra JA;Wegener C
通讯作者：
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影响因子：
64.5
作者：
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通讯作者：
Aerts S
影响因子：
2.5
作者：
Busch, Sebastian;Selcho, Mareike;Tanimoto, Hiromu
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Tanimoto, Hiromu