Resting-state regional cerebral blood flow during adolescence: associations with initiation of substance use and prediction of future use disorders.
Resting-state regional cerebral blood flow during adolescence: associations with initiation of substance use and prediction of future use disorders.
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DOI：
10.1016/j.drugalcdep.2015.01.012
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发表时间：
2015-04-01
影响因子：
4.2
通讯作者：
Williamson, Douglas E.
中科院分区：
文献类型：
--
作者：
Ramage, Amy E.;Lin, Ai-Ling;Olvera, Rene L.;Fox, Peter T.;Williamson, Douglas E.
青春期是发育变化的时期，大脑系统容易受到早期物质使用的影响，这反过来又传递了物质使用障碍风险的增加。我们的研究目的是评估青少年局部脑血流量(RCBF)与当前和未来饮酒的关系。其目的是确定基于大脑的预测因素，预测酒精使用的开始和未来物质使用障碍的发生。对100名青少年(12-15岁)进行了rCBF定量测定。在为期三年的随访期内，每年进行前瞻性行为评估，以确定饮酒开始、未来饮酒模式和使用障碍的特征。在使用组之间的比较(即，当前、未来和不饮酒的青少年)确定了rCBF与开始饮酒有关。通过对未来饮酒模式的回归发现，rCBF预示着更多的饮酒。生存分析确定基线rCBF是否预示使用障碍的后期发展。在目前饮酒和将来饮酒的青少年中，基线rCBF降低到顶叶皮质，增加到中边缘区域。在这个队列中，左侧梭形回的rCBF基线较高，右侧顶叶下皮质和左侧小脑的rCBF较低，与未来的饮酒模式有关，并可预测酒精和药物使用障碍的发生。静息rCBF的变化到奖赏和默认模式或控制网络内的区域似乎代表了酒精使用开始的特征标志，并预测了使用障碍的未来发展。
Adolescence is a period of developmental flux when brain systems are vulnerable to influences of early substance use, which in turn relays increased risk for substance use disorders. Our study intent was to assess adolescent regional cerebral blood flow (rCBF) as it relates to current and future alcohol use. The aim was to identify brain-based predictors for initiation of alcohol use and onset of future substance use disorders. Quantitative rCBF was assessed in 100 adolescents (age 12-15). Prospective behavioral assessments were conducted annually over a three-year follow-up period to characterize onset of alcohol initiation, future drinking patterns and use disorders. Comparisons amongst use groups (i.e., Current-, Future-, and Non-alcohol Using adolescents) identified rCBF associated with initiation of alcohol use. Regression by future drinking patterns identified rCBF predictive of heavier drinking. Survival analysis determined whether or not baseline rCBF predicted later development of use disorders. Baseline rCBF was decreased to the parietal cortex and increased to mesolimbic regions in adolescents currently using alcohol as well as those who would use alcohol in the future. Higher baseline rCBF to the left fusiform gyrus and lower rCBF to the right inferior parietal cortex and left cerebellum was associated with future drinking patterns as well as predicted the onset of alcohol and substance use disorders in this cohort. Variations in resting rCBF to regions within reward and default mode or control networks appear to represent trait markers of alcohol use initiation and is predictive of future development of use disorders.
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