The influence of substance use on adolescent brain development.

The influence of substance use on adolescent brain development.
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DOI:
10.1177/155005940904000110
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发表时间:
2009-01
影响因子:
2
通讯作者:
Tapert SF
Tapert SF
中科院分区:
医学4区
文献类型:
--
作者:
Squeglia LM;Jacobus J;Tapert SF

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青春期是神经发育的一个独特时期。饮酒和吸食大麻很常见。最近的研究表明,青少年药物使用者在大脑功能方面表现出异常,这与随着时间的推移神经认知的变化有关。在大脑结构体积、白质质量和对认知任务的激活方面都可以看到异常,甚至在只有1-2年重度饮酒和每月饮酒20杯的青少年中也是如此,特别是在一次饮用100 - 4-5杯的情况下。重度大麻使用者也表现出一些微妙的异常,但总体上与人口统计学上相似的不使用大麻的青少年的差异程度不同。本文回顾了青少年药物使用者的神经认知、大脑结构和大脑功能方面的现有文献,重点介绍了最常用的药物,以及正在进行的神经成熟过程。提供了方法和治疗意义。
Adolescence is a unique period in neurodevelopment. Alcohol and marijuana use are common. Recent research has indicated that adolescent substance users show abnormalities on measures of brain functioning, which is linked to changes in neurocognition over time. Abnormalities have been seen in brain structure volume, white matter quality, and activation to cognitive tasks, even in youth with as little as 1–2 years of heavy drinking and consumption levels of 20 drinks per month, especially if >4–5 drinks are consumed on a single occasion. Heavy marijuana users show some subtle anomalies too, but generally not the same degree of divergence from demographically similar non-using adolescents. This article reviews the extant literature on neurocognition, brain structure, and brain function in adolescent substance users with an emphasis on the most commonly used substances, and in the context of ongoing neuromaturational processes. Methodological and treatment implications are provided.
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发表时间: 2004-05-25
影响因子: 11.1
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