[(18)F]FDOPA positron emission tomography in manganese-exposed workers.
[(18)F]FDOPA positron emission tomography in manganese-exposed workers.
复制标题
DOI：
10.1016/j.neuro.2017.07.004
复制
发表时间：
2018-01
期刊：
影响因子：
3.4
通讯作者：
Racette BA
中科院分区：
文献类型：
--
作者：
Criswell SR;Nielsen SS;Warden M;Perlmutter JS;Moerlein SM;Flores HP;Huang J;Sheppard L;Seixas N;Checkoway H;Racette BA
职业性锰暴露与帕金森病的发生有关；然而，神经毒性的机制尚不清楚。脑正电子发射断层扫描（PET）成像提供了一种评估多巴胺神经元功能的非侵入性方法。6-[18F]氟左旋多巴（FDOPA） PET反映体内黑质纹状体功能，但Mn暴露的结果是相互矛盾的。本研究的目的是调查职业焊接继发性锰暴露、FDOPA纹状体摄取和临床帕金森病（统一帕金森病评定量表运动亚评分3 （UPDRS3）评分）之间的关系。对72名受试者进行了FDOPA PET扫描（27名mn暴露焊工，14名其他mn暴露工人和31名未暴露受试者）。我们从详细的工作经历中估计了累积的焊接暴露，并由运动障碍专家对所有受试者进行了检查。对每个受试者的纹状体体积进行对齐磁共振成像（MRI）鉴定。用图形分析方法计算纹状体FDOPA摄取比。在调整年龄的同时，我们使用线性回归来评估焊接暴露与尾状核、前壳核和后壳核中FDOPA摄取之间的关系。与未接触锰的受试者相比，接触锰的焊工的平均尾状FDOPA摄取量低0.0014 min - 1(95%可信区间[CI] 0.0008, 0.0020)，其他接触锰的工人的平均尾状FDOPA摄取量低0.0012 min - 1 (95% CI 0.0005, 0.0019) （p均≤0.001）。尾状体FDOPA摄取与Mn暴露或UPDRS3评分之间没有明确的剂量反应关联。mn暴露的焊工和工人表现出较低的尾状FDOPA摄取，表明mn暴露的受试者突触前多巴胺能功能障碍与临床帕金森病无关。
Occupational manganese (Mn) exposure is associated with the development of parkinsonism; however, the mechanism of neurotoxicity is unknown. Brain positron emission tomography (PET) imaging provides a non-invasive method of assessing dopamineric neuronal function. 6-[18F]fluoro-L-DOPA (FDOPA) PET reflects in-vivo nigrostriatal function, but results in Mn exposure are conflicting. The objective of this study was to investigate the association between Mn exposure secondary to occupational welding, FDOPA striatal uptake, and clinical parkinsonism as measured by Unified Parkinson Disease Rating Scale motor subscore 3 (UPDRS3) scores. FDOPA PET scans were acquired on 72 subjects (27 Mn-exposed welders, 14 other Mn-exposed workers, and 31 non-exposed subjects). We estimated cumulative welding exposure from detailed work histories, and a movement disorders specialist examined all subjects. Striatal volumes of interest were identified on aligned magnetic resonance imaging (MRI) for each subject. Specific striatal FDOPA uptake was calculated with a graphical analysis method. We used linear regression while adjusting for age to assess the association between welding exposure and FDOPA uptake in the caudate, anterior putamen, and posterior putamen. Compared to the non-exposed subjects, mean caudate FDOPA uptake was 0.0014 min−1 (95% confidence interval [CI] 0.0008, 0.0020) lower in Mn-exposed welders and 0.0012 min−1 (95% CI 0.0005, 0.0019) lower in other Mn-exposed workers (both p ≤ 0.001). There was no clear dose-response association between caudate FDOPA uptake and Mn exposure or UPDRS3 scores. Mn-exposed welders and workers demonstrated lower caudate FDOPA uptake, indicating pre-synaptic dopaminergic dysfunction in Mn-exposed subjects that was not associated with clinical parkinsonism.
登录
查看更多内容
影响因子：
2
作者：
Hobson AJ;Sterling DA;Emo B;Evanoff BA;Sterling CS;Good L;Seixas N;Checkoway H;Racette BA
通讯作者：
Racette BA
影响因子：
3.7
作者：
Fitsanakis VA;Zhang N;Garcia S;Aschner M
通讯作者：
Aschner M
影响因子：
3.5
作者：
Al-Lozi A;Nielsen SS;Hershey T;Birke A;Checkoway H;Criswell SR;Racette BA
通讯作者：
Racette BA
影响因子：
11.2
作者：
Brooks, DJ
通讯作者：
Brooks, DJ
影响因子：
3.4
作者：
Gonzalez-Cuyar, Luis F.;Nelson, Gill;Criswell, Susan R.;Ho, Pokuan;Lonzanida, Jaymes A.;Checkoway, Harvey;Seixas, Noah;Gelman, Benjamin B.;Evanoff, Bradley A.;Murray, Jill;Zhang, Jing;Racette, Brad A.
通讯作者：
Racette, Brad A.