Prevalence and Correlates of Motoric Cognitive Risk Syndrome in Chinese Community-Dwelling Older Adults.
Prevalence and Correlates of Motoric Cognitive Risk Syndrome in Chinese Community-Dwelling Older Adults.
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DOI：
10.3389/fragi.2022.895138
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发表时间：
2022
影响因子：
--
通讯作者：
Lin, Zhanyi
中科院分区：
文献类型：
--
作者：
Bai, Anying;Xu, Weihao;Lin, Zhanyi
背景：运动认知风险（MCR）综合征被认为是痴呆前期综合征。尽管越来越多的研究开始关注这一综合征，但在中国开展的调查却很少。本研究旨在调查中国 MCR 的患病率及其相关性。 方法：我们纳入了中国健康与退休追踪研究 (CHARLS) 中的 5,725 名 60 岁以上成年人。 MCR 被定义为存在主观认知问题，并且步态速度≤根据性别和身高调整的加权人口分布的第 20 个百分位。使用多元逻辑回归分析检查选定的可修改相关因素和临床测量与 MCR 之间的关联。 结果：在参与者中，414 人符合 MCR 标准，总体患病率为 7.29%（95% CI：6.62-7.96%）。研究发现，MCR 在女性中比男性更普遍（9.73% vs 4.85%），并且在≥75 岁的参与者中比 <75 岁的参与者更普遍（7.85% vs 5.23%）。经过多变量调整后，发现下肢或上肢功能受限、日常生活活动（ADL）障碍、握力较弱、疲惫和高血压病史与 MCR 显着相关。多变量分析还显示，较高水平的半胱氨酸蛋白酶抑制剂 C 和 C 反应蛋白与 MCR 几率增加相关。 结论：本研究表明，MCR 综合征在中国社区老年人中非常普遍，并揭示了与 MCR 相关的几个因素。有必要进行纵向研究来进一步探索 MCR 的可改变危险因素。
Background: Motoric cognitive risk (MCR) syndrome is considered to be a pre-dementia syndrome. Although an increasing number of studies have begun to focus on this syndrome, few investigations have been launched in China. This study was performed to examine the prevalence and correlates of MCR in China. Methods: We included 5,725 adults aged over 60 years from China Health and Retirement Longitudinal Study (CHARLS). MCR was defined as the presence of subjective cognitive complaints and a gait speed ≤20th percentile of the weighted population distribution adjusted for sex and height. The associations among selected modifiable associated factors and clinical measures with MCR were examined using multivariate logistic regression analysis. Results: Of the participants, 414 met the criteria for MCR with an overall prevalence 7.29% (95% CI: 6.62–7.96%). MCR was found to be more prevalent among women than men (9.73 vs 4.85%), and more prevalent among participants ≥75 years than those <75 years (7.85 vs 5.23%). After multivariable adjustment, lower or upper extremity functional limitations, activities of daily living (ADL) disabilities, weak grip strength, exhaustion, and history of hypertension were found to be significantly associated with MCR. The multivariate analysis also showed higher levels of cystatin C and C-reactive protein were associated with increased odds for MCR. Conclusions: The present study showed that MCR syndrome is highly prevalent among Chinese community-dwelling older adults, and revealed several factors that were correlated with MCR. Longitudinal studies are warranted to further explore the modifiable risk factors of MCR.
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DOI：
10.1016/j.jalz.2016.12.013
发表时间：
2017-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Bender AC;Austin AM;Grodstein F;Bynum JPW
通讯作者：
Bynum JPW
影响因子：
3.7
作者：
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通讯作者：
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影响因子：
11.9
作者：
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通讯作者：
Meguro, Kenichi
影响因子：
5.8
作者：
Aguilar-Navarro, S. G.;Mimenza-Alvarado, A. J.;Mejia-Arango, S.
通讯作者：
Mejia-Arango, S.
影响因子：
14
作者：
Ayers, Emmeline;Verghese, Joe
通讯作者：
Verghese, Joe