The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis.
The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis.
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DOI：
10.1016/j.clp.2010.03.002
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发表时间：
2010-06
影响因子：
2.1
通讯作者：
Buhimschi CS
中科院分区：
文献类型：
--
作者：
Buhimschi IA;Buhimschi CS
宫内感染被认为是一种独特的病理过程，大大增加了早发性新生儿败血症（EONS）的风险。通过与早产协同作用，EONS增加了新生儿不良结局的风险，包括脑室内出血（IVH）和脑瘫，这些通常是败血症的后遗症。虽然已经提出了几个不同的途径胎儿损伤的发病机制，调节这些事件的基本分子机制仍然不完全清楚。因此，发现临床和生物学相关的生物标志物，能够揭示关键的致病途径，并预测怀孕的产前胎儿损伤的风险是一个优先事项。蛋白质组学为填补这一空白提供了独特的机会。在短期内，蛋白质组学生物标志物可能有助于医疗决策，包括递送时间和类固醇给药。在长期内，蛋白质组学生物标志物可能导致针对EONS致病性变体的靶向治疗的发展。在此，我们旨在说明该主题的丰富性，并为发现新的蛋白质组生物标志物是改善预后和预防长期残疾的关键步骤这一论点奠定基础。
Intra-uterine infection is viewed as a unique pathological process which raises considerably the risk for early onset neonatal sepsis (EONS). By acting synergistically with prematurity, EONS increases the risk for adverse neonatal outcomes including intraventricular hemorrhage (IVH) and cerebral palsy which are often encountered as sequelae of sepsis. Although several distinct pathways for the pathogenesis of fetal damage have been proposed, the basic molecular mechanisms that modulate these events remain incompletely understood. Therefore, discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap. In the short run proteomic biomarkers may aid with medical decision-making including timing of delivery and steroid administration In the long run proteomic biomarkers may lead to development of targeted therapies against pathogenic variants of EONS. Herein, we aimed to illustrate the richness of the topic and set the stage for the argument that discovery of novel proteomic biomarkers is a critical step in improving outcomes and preventing long-term disability.
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影响因子：
7.2
作者：
Buhimschi, Irina A.;Zambrano, Eduardo;Buhimschi, Catalin S.
通讯作者：
Buhimschi, Catalin S.
DOI：
10.1111/j.1471-0528.2004.00340.x
发表时间：
2005-02-01
影响因子：
5.8
作者：
Buhimschi, IA;Christner, R;Buhimschi, CS
通讯作者：
Buhimschi, CS
影响因子：
9.8
作者：
Cobo, Teresa;Palacio, Montse;Gratacos, Eduard
通讯作者：
Gratacos, Eduard
影响因子：
5.1
作者：
De Felice, C;Toti, P;Bracci, R
通讯作者：
Bracci, R
影响因子：
6
作者：
Buhimschi, Catalin S.;Baumbusch, Margaret A.;Buhimschi, Irina A.
通讯作者：
Buhimschi, Irina A.