Distinct developmental growth patterns account for the disproportionate expansion of the rostral and caudal isocortex in evolution.
Distinct developmental growth patterns account for the disproportionate expansion of the rostral and caudal isocortex in evolution.
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DOI：
10.3389/fnhum.2014.00190
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发表时间：
2014
影响因子：
2.9
通讯作者：
Charvet CJ
中科院分区：
文献类型：
--
作者：
Charvet CJ
在成年期，几个物种的等皮质的特点是每单位皮质表面积的神经元的梯度与较少的神经元每单位皮质表面积在吻极相对于尾极。神经发生时间的梯度预测的差异，在整个isocortex的神经元：每单位皮质表面积的神经元是吻，神经发生持续时间短，和更高的尾神经发生持续时间较长。神经发生持续时间的物种差异如何影响其轴上的皮质祖细胞尚不清楚。我估计祖细胞每单位的心室面积跨越吻尾轴的同皮质猫（猫卡图斯）和狗（犬）主要是在层VI-II神经元的产生。我还估计了两个物种在不同的发展阶段，在喙尾轴的心室长度。选择这两个物种是因为与猫相比，犬的神经发生持续时间延长。在尾部，与猫相比，狗的皮质祖细胞在数量上和切向上扩展得更多。与猫相比，犬的喙部皮质增生区更切向扩张。然而，在吻侧皮质增生区的切向扩张发生没有伴随祖细胞数量的增加。在吻侧皮质中心室表面的切向扩张是由细胞密度的减少介导的。这些不同的发育生长模式解释了喙部的不成比例的扩张（即，额叶皮层）和尾侧皮层（例如，初级视觉皮层），当神经发生持续时间延长的进化。
In adulthood, the isocortex of several species is characterized by a gradient in neurons per unit of cortical surface area with fewer neurons per unit of cortical surface area in the rostral pole relative to the caudal pole. A gradient in neurogenesis timing predicts differences in neurons across the isocortex: neurons per unit of cortical surface area are fewer rostrally, where neurogenesis duration is short, and higher caudally where neurogenesis duration is longer. How species differences in neurogenesis duration impact cortical progenitor cells across its axis is not known. I estimated progenitor cells per unit of ventricular area across the rostro-caudal axis of the isocortex in cats (Felis catus) and in dogs (Canis familiaris) mostly before layers VI-II neurons are generated. I also estimated the ventricular length across the rostro-caudal axis at various stages of development in both species. These two species were chosen because neurogenesis duration in dogs is extended compared with cats. Caudally, cortical progenitors expand more tangentially and in numbers in dogs compared with cats. Rostrally, the cortical proliferative zone expands more tangentially in dogs compared with cats. However, the tangential expansion in the rostral cortical proliferative zone occurs without a concomitant increase in progenitor cell numbers. The tangential expansion of the ventricular surface in the rostral cortex is mediated by a reduction in cell density. These different developmental growth patterns account for the disproportionate expansion of the rostral (i.e., frontal cortex) and caudal cortex (e.g., primary visual cortex) when neurogenesis duration lengthens in evolution.
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影响因子：
2.9
作者：
Herculano-Houzel S;Watson C;Paxinos G
通讯作者：
Paxinos G
影响因子：
--
作者：
ABERCROMBIE, M
通讯作者：
ABERCROMBIE, M
DOI：
10.1073/pnas.1010356107
发表时间：
2010-09-07
影响因子：
11.1
作者：
Collins, Christine E.;Airey, David C.;Kaas, Jon H.
通讯作者：
Kaas, Jon H.
灵长类同皮质神经元密度和数量的系统性平衡梯度。
影响因子：
2.9
作者：
Cahalane DJ;Charvet CJ;Finlay BL
通讯作者：
Finlay BL
影响因子：
3.7
作者：
Gohlke, Julia M.;Griffith, Wifliani C.;Faustman, Elaine M.
通讯作者：
Faustman, Elaine M.