Distribution of neurons in functional areas of the mouse cerebral cortex reveals quantitatively different cortical zones.
Distribution of neurons in functional areas of the mouse cerebral cortex reveals quantitatively different cortical zones.
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DOI：
10.3389/fnana.2013.00035
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发表时间：
2013
影响因子：
2.9
通讯作者：
Paxinos G
中科院分区：
文献类型：
--
作者：
Herculano-Houzel S;Watson C;Paxinos G
神经元是如何沿着皮质表面和跨功能区分布的？在这里，我们使用各向同性分馏器（Herculano-Houzel和Lent）来分析神经元在小鼠整个同皮质的分布，分为18个功能区定义的解剖。我们发现，表面区域下方的神经元数量（N/A比）在功能区域之间变化4.5倍，神经元密度变化3.2倍。S1的面区含有最多的神经元，其次是运动皮层和初级视觉皮层。值得注意的是，虽然神经元在功能区的分布并不伴随着表面积的分布，但它密切反映了皮质体积的分布--除了视觉区，视觉区容纳的神经元比预期的要多。在非视觉皮层中，各个功能区域的体积是其神经元数量的共享线性函数，而在视觉区域中，神经元密度远高于所有其他区域。相反，18个功能区根据N/A比与皮质厚度和神经元密度之间的关系聚类为三个不同的区域：这三个聚类可以称为视觉、感觉和可能的联想。这些发现与人类大脑皮层中的发现非常相似（Ribeiro等人，）并表明，与人类大脑皮层一样，小鼠大脑皮层包括两个区域，这两个区域在神经元如何形成皮层体积方面有所不同，以及三个区域，这三个区域在神经元如何分布在皮层表面之下方面有所不同，这可能与通过白色物质的连通性的局部差异有关。我们的研究结果表明，超越发展划分为视觉和非视觉皮层，功能区最初共享一个共同的分布神经元沿着的实质，成为划定功能区根据后来建立的连接模式。
How are neurons distributed along the cortical surface and across functional areas? Here we use the isotropic fractionator (Herculano-Houzel and Lent,) to analyze the distribution of neurons across the entire isocortex of the mouse, divided into 18 functional areas defined anatomically. We find that the number of neurons underneath a surface area (the N/A ratio) varies 4.5-fold across functional areas and neuronal density varies 3.2-fold. The face area of S1 contains the most neurons, followed by motor cortex and the primary visual cortex. Remarkably, while the distribution of neurons across functional areas does not accompany the distribution of surface area, it mirrors closely the distribution of cortical volumes—with the exception of the visual areas, which hold more neurons than expected for their volume. Across the non-visual cortex, the volume of individual functional areas is a shared linear function of their number of neurons, while in the visual areas, neuronal densities are much higher than in all other areas. In contrast, the 18 functional areas cluster into three different zones according to the relationship between the N/A ratio and cortical thickness and neuronal density: these three clusters can be called visual, sensory, and, possibly, associative. These findings are remarkably similar to those in the human cerebral cortex (Ribeiro et al.,) and suggest that, like the human cerebral cortex, the mouse cerebral cortex comprises two zones that differ in how neurons form the cortical volume, and three zones that differ in how neurons are distributed underneath the cortical surface, possibly in relation to local differences in connectivity through the white matter. Our results suggest that beyond the developmental divide into visual and non-visual cortex, functional areas initially share a common distribution of neurons along the parenchyma that become delimited into functional areas according to the pattern of connectivity established later.
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DOI：
10.1073/pnas.0611723104
发表时间：
2007-03-06
影响因子：
11.1
作者：
Leingartner, Axel;Thuret, Sandrine;O'Leary, Dennis D. M.
通讯作者：
O'Leary, Dennis D. M.
DOI：
10.1073/pnas.1010356107
发表时间：
2010-09-07
影响因子：
11.1
作者：
Collins, Christine E.;Airey, David C.;Kaas, Jon H.
通讯作者：
Kaas, Jon H.
灵长类同皮质神经元密度和数量的系统性平衡梯度。
影响因子：
2.9
作者：
Cahalane DJ;Charvet CJ;Finlay BL
通讯作者：
Finlay BL
DOI：
10.1073/pnas.0604911103
发表时间：
2006-08-08
影响因子：
11.1
作者：
Herculano-Houzel, Suzana;Mota, Bruno;Lent, Roberto
通讯作者：
Lent, Roberto
影响因子：
1.7
作者：
Finlay, BL;Hersman, MN;Darlington, RB
通讯作者：
Darlington, RB