Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner.
Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner.
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DOI：
10.4049/jimmunol.1101859
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发表时间：
2012-05-01
期刊：
影响因子：
--
通讯作者：
Mitre E
中科院分区：
文献类型：
--
作者：
Larson D;Hübner MP;Torrero MN;Morris CP;Brankin A;Swierczewski BE;Davies SJ;Vonakis BM;Mitre E
嗜碱性粒细胞在过敏性疾病和蠕虫感染的2型免疫应答的发展和效应阶段中起关键作用。这项研究表明，嗜碱性粒细胞成为IgE介导的刺激时，小鼠慢性感染Litomosoides sigmodontis，一种丝虫，血吸虫曼氏血吸虫，血吸虫。虽然从微丝蚴的排泄/分泌产物的L。sigmodontis在体外抑制嗜碱性粒细胞，微丝蚴转移到小鼠体内不会导致嗜碱性粒细胞抑制。相反，嗜碱性粒细胞反应性降低（需要存在活蠕虫）被发现依赖于宿主IL-10，并伴随着已知由IL-10下调的关键IgE信号分子的减少。鉴于嗜碱性粒细胞在2型免疫反应发展中的重要性，这些发现有助于解释蠕虫保护过敏的机制，并可能对理解蠕虫感染如何改变人们的其他疾病状态产生广泛的影响。
Basophils play a key role in the development and effector phases of type 2 immune responses in both allergic diseases and helminth infections. This study shows that basophils become less responsive to IgE-mediated stimulation when mice are chronically infected with Litomosoides sigmodontis, a filarial nematode, and Schistosoma mansoni, a blood fluke. Although excretory/secretory products from microfilariae of L. sigmodontis suppressed basophils in vitro, transfer of microfilariae into mice did not result in basophil suppression. Rather, reduced basophil responsiveness, which required the presence of live helminths, was found to be dependent on host IL-10 and was accompanied by decreases in key IgE signaling molecules known to be downregulated by IL-10. Given the importance of basophils in the development of type 2 immune responses, these findings help explain the mechanism by which helminths protect against allergy and may have broad implications for understanding how helminth infections alter other disease states in people.
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DOI：
10.1111/j.1365-2222.2010.03559.x
发表时间：
2010-11
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Endara P;Vaca M;Chico ME;Erazo S;Oviedo G;Quinzo I;Rodriguez A;Lovato R;Moncayo AL;Barreto ML;Rodrigues LC;Cooper PJ
通讯作者：
Cooper PJ
影响因子：
2.2
作者：
Marechal, P;LeGoff, L;Petit, G
通讯作者：
Petit, G
使用鼻内猫过敏原激发，奥马珠单抗对嗜碱性粒细胞和肥大细胞反应的影响。
影响因子：
14.2
作者：
Eckman, John A.;Sterba, Patricia M.;Kelly, Denise;Alexander, Val;Liu, Mark C.;Bochner, Bruce S.;MacGlashan, Donald W., Jr.;Saini, Sarbjit S.
通讯作者：
Saini, Sarbjit S.
影响因子：
4.4
作者：
MacGlashan, Donald, Jr.;Vilarino, Natalia
通讯作者：
Vilarino, Natalia
DOI：
10.1097/aci.0b013e32831f44a6
发表时间：
2009-02
影响因子：
2.8
作者：
Cooper PJ
通讯作者：
Cooper PJ