The Effect of Cumulative Lifetime Estrogen Exposure on Cognition in Depressed Versus Non-Depressed Older Women.
The Effect of Cumulative Lifetime Estrogen Exposure on Cognition in Depressed Versus Non-Depressed Older Women.
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DOI：
10.1177/08919887221090216
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发表时间：
2022-11
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
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三分之二的阿尔茨海默病患者是女性。雌激素水平下降影响情绪和认知。累积终生雌激素暴露（CLEE）与以后的生活中的认知相关。我们研究了CLEE与抑郁症和认知的关系，在老年妇女与抑郁症相比，非抑郁症的妇女。采用终生雌激素暴露问卷，将患有抑郁症的老年女性（年龄≥60岁）与非抑郁症女性进行比较。CLEE定义为生育期（绝经年龄减去初潮年龄）和任何绝经后激素替代治疗使用的综合持续时间。较高与较低CLEE组基于474个月的雌激素暴露中位数。大学医院门诊研究项目135名≥60岁的女性，64名抑郁症患者和71名非抑郁症患者完成了一项综合认知测试。一般线性模型被用来检查抑郁症和非抑郁症妇女的认知领域得分和CLEE之间的关联，控制年龄，教育和种族。抑郁组和非抑郁组的CLEE水平存在显著差异，以月为单位测量：平均值为495.7（SD 108.6）vs 456.4（SD 66.0）个月，F（1，130）= 5.01，p = 0.03。在非抑郁的参与者中，较高的CLEE与延迟回忆的改善相关（F（1，59）= 5.94，p = 0.02，效应量= 0.61），而在抑郁组中没有观察到这种关系。较高的CLEE与非抑郁症患者延迟回忆的改善相关，但与抑郁症患者无关。这表明雌激素对非抑郁的绝经后老年妇女的记忆有保护作用。进一步的研究应该检查CLEE在抗抑郁反应和认知能力下降中的作用。
Two-thirds of individuals living with Alzheimer’s disease are women. Declining estrogen levels influence mood and cognition. Cumulative lifetime estrogen exposure (CLEE) correlates with cognition later in life. We examined the relationship of CLEE to depression and cognition in older women with major depression compared to non-depressed women. Older women (age ≥60 years) with depression were compared to non-depressed women using a lifetime estrogen exposure questionnaire. CLEE was defined as combined durations of reproductive span (age of menopause minus age of menarche) and any post-menopausal hormone replacement therapy use. Higher vs lower CLEE groups were based on a median of 474 months of estrogen exposure. University hospital outpatient research program 135 women ≥60 years; 64 depressed and 71 non-depressed Participants completed a comprehensive cognitive test battery. General linear models were used to examine the association between cognitive domain scores and CLEE in depressed and non-depressed women, controlling for age, education, and ethnicity. Depressed and non-depressed groups had significantly different levels of CLEE, measured in months: mean 495.7 (SD 108.6) vs 456.4 (SD 66.0) months, F(1,130) = 5.01, p = .03. Within the non-depressed participants, higher CLEE was associated with improved delayed recall (F(1,59) = 5.94, p = .02, effect size = .61), while no such relationship was observed in the depressed group. Higher CLEE was associated with improvement in delayed recall among non-depressed, but not among depressed participants. This suggests a protective role of estrogen on memory in non-depressed older postmenopausal women. Further research should examine the role of the CLEE in antidepressant response and cognitive decline.
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影响因子：
4.1
作者：
Li, Rena;Cui, Jie;Shen, Yong
通讯作者：
Shen, Yong
影响因子：
--
作者：
Lacritz, L H;Cullum, C M;Rosenberg, R N
通讯作者：
Rosenberg, R N
DOI：
10.1177/1533317518786447
发表时间：
2018-12
期刊：
American journal of Alzheimer's disease and other dementias
影响因子：
--
作者：
Fox M;Berzuini C;Knapp LA;Glynn LM
通讯作者：
Glynn LM
影响因子：
3.7
作者：
Prince MJ;Acosta D;Guerra M;Huang Y;Jimenez-Velazquez IZ;Llibre Rodriguez JJ;Salas A;Sosa AL;Chua KC;Dewey ME;Liu Z;Mayston R;Valhuerdi A
通讯作者：
Valhuerdi A
DOI：
10.1177/1745506518817995
发表时间：
2018-12-26
期刊：
Women's Health
影响因子：
--
作者：
Andrew MK;Tierney MC
通讯作者：
Tierney MC