Activatable interpolymer complex-superparamagnetic iron oxide nanoparticles as magnetic resonance contrast agents sensitive to oxidative stress.
Activatable interpolymer complex-superparamagnetic iron oxide nanoparticles as magnetic resonance contrast agents sensitive to oxidative stress.
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DOI：
10.1016/j.colsurfb.2017.07.025
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发表时间：
2017-10-01
期刊：
影响因子：
--
通讯作者：
Doiron AL
中科院分区：
文献类型：
--
作者：
Yoo E;Cheng HA;Nardacci LE;Beaman DJ;Drinnan CT;Lee C;Fishbein KW;Spencer RG;Fisher OZ;Doiron AL
磁共振造影剂可以响应特定的触发而被激活，作为分子生物传感器具有潜力，可能在非侵入性疾病诊断中有很大的用处。我们开发了一种基于超顺磁性氧化铁纳米颗粒（SPIOs）的活化剂，它对氧化应激敏感，这是许多疾病的病理生理因素。spio表面涂有聚乙二醇（PEG），并与合成单宁聚没食子醇（聚没食子醇）络合。聚乙二醇和聚乙二醇之间的氢键在SPIO周围形成了一个复杂的层，减少了溶质水与SPIO的相互作用，减弱了它的磁共振弛缓性。复合聚合物间纳米颗粒处于OFF状态（T2对比度降低），其中造影剂具有7±2 mM−1 s−1的低T2弛豫度。在超氧化物的存在下，聚乙二醇被氧化，聚合物分解，使溶质水再次与SPIO相互作用，表现为ON状态（增加T2对比度），T2弛度为70±10 mM−1 s−1。这些造影剂有望成为部分以氧化应激为特征的疾病（如动脉粥样硬化、糖尿病和癌症）的有效传感器。
Magnetic resonance contrast agents that can be activated in response to specific triggers hold potential as molecular biosensors that may be of great utility in non-invasive disease diagnosis. We developed an activatable agent based on superparamagnetic iron oxide nanoparticles (SPIOs) that is sensitive to oxidative stress, a factor in the pathophysiology of numerous diseases. SPIOs were coated with poly(ethylene glycol) (PEG) and complexed with poly(gallol), a synthetic tannin. Hydrogen bonding between PEG and poly(gallol) creates a complexed layer around the SPIO that decreases the interaction of solute water with the SPIO, attenuating its magnetic resonance relaxivity. The complexed interpolymer nanoparticle is in an OFF state (decreased T2 contrast), where the contrast agent has a low T2 relaxivity of 7 ± 2 mM−1 s−1. In the presence of superoxides, the poly(gallol) is oxidized and the polymers decomplex, allowing solute water to again interact with the SPIO, representing an ON state (increased T2 contrast) with a T2 relaxivity of 70 ± 10 mM−1 s−1. These contrast agents show promise as effective sensors for diseases characterized in part by oxidative stress such as atherosclerosis, diabetes, and cancer.
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影响因子：
10.8
作者：
Kojda, G;Laursen, JB;Harrison, DG
通讯作者：
Harrison, DG
影响因子：
3.4
作者：
Cheng, H. A.;Drinnan, C. T.;Fisher, O. Z.
通讯作者：
Fisher, O. Z.
影响因子：
7.7
作者：
Baynes, JW;Thorpe, SR
通讯作者：
Thorpe, SR
DOI：
10.1016/j.msec.2009.01.005
发表时间：
2009-06-01
期刊：
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
影响因子：
--
作者：
Bahadur K C, Remant;Lee, So Min;Do Ghim, Han
通讯作者：
Do Ghim, Han
DOI：
10.1016/s0927-7757(00)00845-1
发表时间：
2001-06-30
影响因子：
5.2
作者：
Boada, J;Gallardo, M;Estelrich, J
通讯作者：
Estelrich, J