Clinical high risk for psychosis: gender differences in symptoms and social functioning
Clinical high risk for psychosis: gender differences in symptoms and social functioning
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精神病的临床高风险：症状和社会功能的性别差异
DOI：
10.1111/eip.12240
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发表时间：
2015
影响因子：
2
通讯作者：
Müller
中科院分区：
文献类型：
--
作者：
Rietschel;Lambert;Müller
目的精神分裂症是一种异质性疾病，在男性和女性中表现不同：男性表现出更高的阴性症状倾向，较低的社会功能，发病年龄较早和共病药物滥用，而女性表现出更多的情感症状。目前尚不清楚这些差异是否延伸到精神病高风险（HR）受试者。因此，本研究的目的是解决这个问题。MethodsClinical symptoms和功能进行了评估，使用结构化访谈239人力资源科目（女性，n= 80）。在人力资源的定义是基于在欧洲的精神病研究预测（EPOS）的标准。ResultsMen表现出更明显的阴性症状，过去的药物滥用障碍和更高的赤字率在社会功能。没有发现性别差异抑郁症，这影响了近50%的队列，或发病年龄为履行HR criteria.ConclusionThe较高的损害，在男性精神分裂症患者中观察到的特定症状也存在于HR为精神病的受试者。需要进一步的研究来确定这些症状是否是向精神病转变的性别特异性预测因素，以及它们是否需要性别特异性干预。与一般人群相比，本队列中抑郁的高倾向性在男性队列中尤其明显，结合观察到的阴性症状和功能障碍的增加，应提醒临床医生有必要识别和治疗HR受试者，无论这些特征与转换风险的相关程度如何。
AimSchizophrenia is a heterogeneous disorder that presents differently in men and women: men show a higher propensity to negative symptoms, lower social functioning, earlier age at onset and co‐morbid substance abuse, whereas women display more affective symptoms. It is unknown whether these differences extend to subjects at high risk (HR) of psychosis. Thus, the aim of the present study was to address this question.MethodsClinical symptoms and functioning were assessed using structured interviews in 239 HR subjects (female,n= 80). The definition of being at HR was based on the criteria used in the European Prediction of Psychosis Study (EPOS).ResultsMen displayed more pronounced negative symptoms, higher rates of past substance abuse disorders and higher deficits in social functioning. No gender difference was found for depression, which affected almost 50% of the cohort, or age at onset for the fulfilment of HR criteria.ConclusionThe higher impairment in specific symptoms observed in male schizophrenia patients was also present in subjects at HR for psychosis. Further studies are required to determine whether these symptoms are gender‐specific predictors of transition to psychosis and whether they warrant gender‐specific interventions. The high propensity to depression in the present cohort, which was particularly pronounced in the male cohort compared with the general population, in conjunction with the observed increase in negative symptoms and functional impairment, should alert clinicians to the necessity for the identification and treatment of HR subjects, irrespective of the degree to which these features are associated with transition risk.
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作者：
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DOI：
10.1176/ps.2006.57.6.844
发表时间：
2006
期刊：
Psychiatric services (Washington, D.C.)
影响因子：
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作者：
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