Using Wolbachia for Dengue Control: Insights from Modelling.
Using Wolbachia for Dengue Control: Insights from Modelling.
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DOI:
10.1016/j.pt.2017.11.002
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发表时间:
2018-03
影响因子:
9.6
通讯作者:
Ferguson NM
中科院分区:
文献类型:
--
作者:
Dorigatti I;McCormack C;Nedjati-Gilani G;Ferguson NM
Dengue is the most common arboviral infection of humans, responsible for a substantial disease burden across the tropics. Traditional insecticide-based vector control programmes have limited effectiveness and the one licensed vaccine has a complex and imperfect efficacy profile. Strains of the bacterium Wolbachia deliberately introduced into Aedes aegypti have been shown to be able to spread to high frequencies in mosquito populations in release trials, and mosquitoes infected with these strains show markedly reduced vector competence. Thus, Wolbachia represents an exciting potential new form of biocontrol for arboviral diseases, including dengue. Here we review how mathematical models give insight into the dynamics of the spread of Wolbachia, its potential impact on dengue transmission and discuss remaining evaluation and development challenges.
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