Benchtop magnetic particle relaxometer for detection, characterization and analysis of magnetic nanoparticles.
Benchtop magnetic particle relaxometer for detection, characterization and analysis of magnetic nanoparticles.
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DOI：
10.1088/1361-6560/aad97d
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发表时间：
2018-09-06
影响因子：
3.5
通讯作者：
Arnold DP
中科院分区：
文献类型：
--
作者：
Garraud N;Dhavalikar R;Unni M;Savliwala S;Rinaldi C;Arnold DP
本文介绍了磁粒子弛豫计（MPR）的设计、构造和测试，以评估磁纳米粒子在受到偏置场时对动态磁场的响应。所设计的MPR可以表征磁颗粒，作为磁颗粒成像（MPI）的示踪剂，通过施加的偏置场的变化来模拟MPI场自由点的扫描。该系统应用高频时变激励场（在30 kHz时高达45 mT），同时缓慢增加偏置场（在1秒内±100 mT）。样品的时间分辨响应使用电感传感线圈系统进行测量，该系统由拾取线圈和旋转平移平衡线圈组成，可以很好地抵消来自激励场的感应馈通。提出了一种用于MPI应用的提取与点扩散函数相关的示踪响应的后处理算法，并使用超顺磁性氧化铁颗粒（铁碳糖酐）演示了MPR的性能。
This paper presents the design, construction, and testing of a magnetic particle relaxometer (MPR) to assess magnetic nanoparticle response to dynamic magnetic fields while subjected to a bias field. The designed MPR can characterize magnetic particles for use as tracers in magnetic particle imaging (MPI), with the variation of an applied bias field emulating the scan of the MPI field free point. The system applies a high-frequency time-varying excitation field (up to 45 mT at 30 kHz), while slowly ramping a bias field (± 100 mT in 1 s). The time-resolved response of the sample is measured using an inductive sensing coil system, made of a pick-up coil and a rotating and translating balancing coil to finely cancel the induction feed-through from the excitation field. A post-processing algorithm is presented to extract the tracer response related to the point spread function for MPI applications, and the performance of the MPR is demonstrated using superparamagnetic iron oxide particles (ferucarbotran).
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