Microdevice Development and Artificial Organs.
Microdevice Development and Artificial Organs.
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微型设备开发和人造器官。
DOI：
10.1111/aor.13288
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发表时间：
2019
影响因子：
2.4
通讯作者：
Zahn,JeffreyD
中科院分区：
文献类型：
--
作者：
Zahn,JeffreyD
在过去的几十年里，微制造医疗传感器和致动器的发展出现了爆炸式增长。从最早开发基于硅的微机电系统或MEMS器件开始，人们就有兴趣开发MEMS技术来支持医疗领域（生物医学MEMS或BioMEMS）（1，2）。其中许多技术对整个医学领域，特别是人工器官领域产生了积极的影响。这些技术将医疗传感器带入诊所、手术室，甚至作为植入式技术（图1）。随着BioMEMS领域的成熟，越来越多的设备被开发为人工微设备和患者之间的主动接口。微制造医疗传感器已经从固态物理传感器（例如用于测量呼吸、血压和流速的力、压力和流量传感器）发展到微制造多电极皮层内刺激和记录阵列（神经探针）（3，4），神经假体（5，6），和基于聚合物的微流体装置（7，8）进行高度灵敏的护理点诊断测定（9）或支持微规模细胞培养或芯片上器官平台（10，11）。在这个时候，我们也开始看到许多这些诊断技术的广泛商业化（12）。这种传感器也是创建传感器化或“智能”产品以及为可穿戴诊断或个性化医疗监护仪创建所谓的“物联网”趋势的一部分（9）。早期的医疗MEMS传感器以固态物理传感器的形式开发，用于测量压力，流量和应变（力）。这种物理传感器是一种成熟的技术，其有助于实现对患者的低成本或自主监测，向临床医生提供诊断信息，或允许对医疗设备进行反馈控制。这些类型的设备已经被用于测量或监测患者的生理参数;诸如血压（13）和流速、肺活量计和呼吸率监测器。它们还可用于监测患者在诊所外的活动，例如嵌入运动设备和头盔中的力传感器或加速度计，以评估脑震荡或损伤，或嵌入鞋类中的压力传感器和加速度计，以评估步态，平衡和足部溃疡风险。这种传感器也已被纳入
Over the past several decades, there has been an explosion in the development of microfabricated medical sensors and actuators. From the earliest development of silicon based MicroElectroMechanical Systems or MEMS devices there has been an interest in developing MEMS technology to support the medical field (biomedical MEMS or BioMEMS)(1, 2). Many of these technologies have positively impacted the medical field in general and the Artificial Organs field in particular. These technologies have brought medical sensors into the clinic, operating rooms or even as implantable technologies (Figure 1). As the BioMEMS field has matured, devices are increasing being developed as an active interface between the artificial microdevice and patients. Microfabricated medical transducers have evolved from solid state physical transducers such as force, pressure and flow sensors for measuring respiration, blood pressure and flow rates, into microfabricated multielectrode intracortical stimulating and recording arrays (neural probes)(3, 4), neural prostheses (5, 6), and polymer based microfluidic devices (7, 8) to perform highly sensitive point of care diagnostic assays (9) or supporting microscale cell cultures or Organ on a Chip platforms (10, 11). At this time we are also beginning to see widespread commercialization of many of these diagnostic technologies (12). Such sensors are also part of the trend of creating sensorized or ‘smart’products and creating the so-called ‘internet of things’ for wearable diagnostics or personalized healthcare monitors (9).Early medical MEMS transducers were developed in the form of solid state physical sensors to measure pressure, flow, and strain (force). Such physical sensors are a mature technology which have been instrumental in enabling low cost or autonomous monitoring of patients, providing diagnostic information to clinicians, or allowing feedback control of medical equipment. These types of devices have been utilized to measure or monitor physiological parameters of a patient; such as blood pressure (13) and flow rates, spirometers, and respiration rate monitors. They can also be used to monitor patient activity outside the clinic such as force sensors or accelerometers embedded in sports equipment and helmets to assess concussion or injuries, or pressure sensors and accelerometers embedded in footwear to assess gait, balance and foot ulcer risk. Such sensors have also been incorporated into
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影响因子：
7.8
作者：
Fissell, William H.;Fleischman, Aaron J.;Roy, Shuvo
通讯作者：
Roy, Shuvo
使用微流体免疫测定设备 - 一项试点研究，在模拟心肺旁路期间对炎症生物标志物进行连续监测。
影响因子：
2.4
作者：
Sasso LA;Aran K;Guan Y;Ündar A;Zahn JD
通讯作者：
Zahn JD
影响因子：
--
作者：
Shrirao AB;Fritz Z;Novik EM;Yarmush GM;Schloss RS;Zahn JD;Yarmush ML
通讯作者：
Yarmush ML
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
A. Mercanzini;P. Renaud
通讯作者：
P. Renaud
影响因子：
6.1
作者：
Ghodbane M;Stucky EC;Maguire TJ;Schloss RS;Shreiber DI;Zahn JD;Yarmush ML
通讯作者：
Yarmush ML