Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population.
Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population.
复制标题
DOI：
10.3390/metabo11090604
复制
发表时间：
2021-09-06
期刊：
影响因子：
4.1
通讯作者：
Velázquez-Cruz R
中科院分区：
文献类型：
--
作者：
Palacios-González B;León-Reyes G;Rivera-Paredez B;Ibarra-González I;Vela-Amieva M;Flores YN;Canizales-Quinteros S;Salmerón J;Velázquez-Cruz R
最近的证据表明，肥胖与骨量呈负相关。然而，传统的人体测量方法，如体重指数，不能区分内脏脂肪组织和皮下脂肪组织。内脏脂肪指数（VAI）是反映内脏脂肪分布和功能的可靠的性别指标。因此，我们的目的是确定与VAI和低骨密度（BMD）相关的代谢组学特征。来自卫生工作者队列研究的总共602人被纳入研究。使用靶向代谢组学方法测量了40种血清代谢物，并使用多元回归模型来测试代谢组学特征与人体测量学、临床和生化参数的相关性。分析显示血清氨基酸特征由甘氨酸、亮氨酸、精氨酸、缬氨酸和酰基肉碱组成，与高VAI和低BMD相关。此外，我们还发现了一个性别依赖的VAI在与初级胆汁酸生物合成、支链氨基酸、泛酸和辅酶a （CoA）的生物合成相关的途径中。综上所述，代谢谱因VAI和BMD状态而异，这些变化是性别依赖性的。
Recent evidence shows that obesity correlates negatively with bone mass. However, traditional anthropometric measures such as body mass index could not discriminate visceral adipose tissue from subcutaneous adipose tissue. The visceral adiposity index (VAI) is a reliable sex-specified indicator of visceral adipose distribution and function. Thus, we aimed to identify metabolomic profiles associated with VAI and low bone mineral density (BMD). A total of 602 individuals from the Health Workers Cohort Study were included. Forty serum metabolites were measured using the targeted metabolomics approach, and multivariate regression models were used to test associations of metabolomic profiles with anthropometric, clinical, and biochemical parameters. The analysis showed a serum amino acid signature composed of glycine, leucine, arginine, valine, and acylcarnitines associated with high VAI and low BMD. In addition, we found a sex-dependent VAI in pathways related to primary bile acid biosynthesis, branched-chain amino acids, and the biosynthesis of pantothenate and coenzyme A (CoA). In conclusion, a metabolic profile differs by VAI and BMD status, and these changes are gender-dependent.
登录
查看更多内容
影响因子：
5
作者：
Khazai, Natasha;Judd, Suzanne E;Tangpricha, Vin
通讯作者：
Tangpricha, Vin
影响因子：
4.3
作者：
De Lorenzo, Antonino;Soldati, Laura;Di Renzo, Laura
通讯作者：
Di Renzo, Laura
DOI：
10.1016/j.numecd.2020.07.010
发表时间：
2020-11-27
影响因子：
3.9
作者：
Dadson, Prince;Rebelos, Eleni;Nuutila, Pirjo
通讯作者：
Nuutila, Pirjo
影响因子：
2.7
作者：
Eshreif, Amina;Al Batran, Rami;Ussher, John R.
通讯作者：
Ussher, John R.
影响因子：
4.6
作者：
Baars A;Oosting A;Lohuis M;Koehorst M;El Aidy S;Hugenholtz F;Smidt H;Mischke M;Boekschoten MV;Verkade HJ;Garssen J;van der Beek EM;Knol J;de Vos P;van Bergenhenegouwen J;Fransen F
通讯作者：
Fransen F