Sex differences in lipid metabolism are affected by presence of the gut microbiota.
Sex differences in lipid metabolism are affected by presence of the gut microbiota.
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DOI：
10.1038/s41598-018-31695-w
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发表时间：
2018-09-07
影响因子：
4.6
通讯作者：
Fransen F
中科院分区：
文献类型：
--
作者：
Baars A;Oosting A;Lohuis M;Koehorst M;El Aidy S;Hugenholtz F;Smidt H;Mischke M;Boekschoten MV;Verkade HJ;Garssen J;van der Beek EM;Knol J;de Vos P;van Bergenhenegouwen J;Fransen F
生理过程在男女之间受到不同的调节。性和肠道微生物群都被证明可以调节宿主的新陈代谢，但目前还不清楚这两个因素是否相互依赖。在这里，我们确定了脂质代谢中的性别特异性差异在多大程度上是通过肠道微生物群调节的。虽然雄性和雌性Conv小鼠在与脂质代谢相关的基因组中表现出主要的差异表达，但GF小鼠在与肠道健康和炎症反应相关的基因组中表现出差异。这表明肠道微生物群的存在在脂质代谢的性别特异性调节中是重要的。此外，我们探讨了胆汁酸作为介质在微生物组和宿主脂质代谢之间的相互作用中的作用。女性显示出较高的总胆汁酸和原发性血清胆汁酸水平，与微生物群的存在无关。然而，在存在微生物群的情况下，我们观察到女性的继发性血清胆汁酸水平高于男性。微生物群组成的分析显示Conv小鼠中存在性别特异性差异。因此，我们的数据表明，胆汁酸可能在微生物组和脂质代谢的性别特异性调节之间的串扰中发挥作用。总之，我们的数据表明，肠道微生物群的存在有助于脂质代谢的性别差异。
Physiological processes are differentially regulated between men and women. Sex and gut microbiota have each been demonstrated to regulate host metabolism, but it is unclear whether both factors are interdependent. Here, we determined to what extent sex-specific differences in lipid metabolism are modulated via the gut microbiota. While male and female Conv mice showed predominantly differential expression in gene sets related to lipid metabolism, GF mice showed differences in gene sets linked to gut health and inflammatory responses. This suggests that presence of the gut microbiota is important in sex-specific regulation of lipid metabolism. Further, we explored the role of bile acids as mediators in the cross-talk between the microbiome and host lipid metabolism. Females showed higher total and primary serum bile acids levels, independent of presence of microbiota. However, in presence of microbiota we observed higher secondary serum bile acid levels in females compared to males. Analysis of microbiota composition displayed sex-specific differences in Conv mice. Therefore, our data suggests that bile acids possibly play a role in the crosstalk between the microbiome and sex-specific regulation of lipid metabolism. In conclusion, our data shows that presence of the gut microbiota contributes to sex differences in lipid metabolism.
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影响因子：
7.9
作者：
Mauvais-Jarvis F
通讯作者：
Mauvais-Jarvis F
影响因子：
6.5
作者：
Kasahara K;Tanoue T;Yamashita T;Yodoi K;Matsumoto T;Emoto T;Mizoguchi T;Hayashi T;Kitano N;Sasaki N;Atarashi K;Honda K;Hirata KI
通讯作者：
Hirata KI
影响因子：
12.2
作者：
Org E;Mehrabian M;Parks BW;Shipkova P;Liu X;Drake TA;Lusis AJ
通讯作者：
Lusis AJ
肠道菌群受性别和体重指数的影响。
影响因子：
3.7
作者：
Haro C;Rangel-Zúñiga OA;Alcalá-Díaz JF;Gómez-Delgado F;Pérez-Martínez P;Delgado-Lista J;Quintana-Navarro GM;Landa BB;Navas-Cortés JA;Tena-Sempere M;Clemente JC;López-Miranda J;Pérez-Jiménez F;Camargo A
通讯作者：
Camargo A
影响因子：
5.3
作者：
Ling, Guoyu;Sugathan, Aarathi;Waxman, David J.
通讯作者：
Waxman, David J.