C-reactive protein gene variants: independent association with late-life depression and circulating protein levels.
C-reactive protein gene variants: independent association with late-life depression and circulating protein levels.
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DOI：
10.1038/tp.2014.145
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发表时间：
2015-01-20
影响因子：
6.8
通讯作者：
Ryan J
中科院分区：
文献类型：
--
作者：
Ancelin ML;Farré A;Carrière I;Ritchie K;Chaudieu I;Ryan J
C-反应蛋白（CRP）是一种全身炎症的遗传生物标志物，通常在抑郁症患者中升高。因此，影响蛋白质水平的CRP基因变异可能与抑郁症有关，但这很少被研究，特别是在老年人中。作为ESPRIT研究的一部分，对990名至少65岁的人进行了抑郁症评估。临床抑郁水平（DEP）定义为流行病学研究中心抑郁量表评分为1.16分，或根据Mini-International Neuropsychiatric Interview和精神疾病诊断与统计手册-IV标准诊断为当前重度抑郁症。对跨越CRP基因的五个单核苷酸多态性进行基因分型，并测定高敏CRP的循环水平。多变量分析调整了社会人口统计学特征、吸烟、缺血性病理、认知障碍和炎症相关慢性病理。在Bonferroni校正的显著性水平上，rs 1130864和rs 1417938的次要等位基因与女性抑郁症风险降低相关（P=0.002）。CRP基因变异以性别特异性方式与血清水平相关，但只有rs 1205被发现与女性DEP风险增加和循环CRP水平降低名义上相关。因此，CRP基因的变异影响循环CRP水平，并作为独立的易感因素出现晚年抑郁症。
C-reactive protein (CRP) is a heritable biomarker of systemic inflammation that is commonly elevated in depressed patients. Variants in the CRP gene that influence protein levels could thus be associated with depression but this has seldom been examined, especially in the elderly. Depression was assessed in 990 people aged at least 65 years as part of the ESPRIT study. A clinical level of depression (DEP) was defined as having a score of ⩾16 on The Center for Epidemiologic Studies Depression scale or a diagnosis of current major depression based on the Mini-International Neuropsychiatric Interview and according to Diagnostic and Statistical Manual of Mental Disorders-IV criteria. Five single-nucleotide polymorphisms spanning the CRP gene were genotyped, and circulating levels of high-sensitivity CRP were determined. Multivariable analyses adjusted for socio-demographic characteristics, smoking, ischemic pathologies, cognitive impairment and inflammation-related chronic pathologies. The minor alleles of rs1130864 and rs1417938 were associated with a decreased risk of depression in women at Bonferroni-corrected significance levels (P=0.002). CRP gene variants were associated with serum levels in a gender-specific manner, but only rs1205 was found to be nominally associated with both an increased risk of DEP and lower circulating CRP levels in women. Variants of the CRP gene thus influence circulating CRP levels and appear as independent susceptibility factors for late-life depression.
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影响因子：
37.8
作者：
Dehghan A;Dupuis J;Barbalic M;Bis JC;Eiriksdottir G;Lu C;Pellikka N;Wallaschofski H;Kettunen J;Henneman P;Baumert J;Strachan DP;Fuchsberger C;Vitart V;Wilson JF;Paré G;Naitza S;Rudock ME;Surakka I;de Geus EJ;Alizadeh BZ;Guralnik J;Shuldiner A;Tanaka T;Zee RY;Schnabel RB;Nambi V;Kavousi M;Ripatti S;Nauck M;Smith NL;Smith AV;Sundvall J;Scheet P;Liu Y;Ruokonen A;Rose LM;Larson MG;Hoogeveen RC;Freimer NB;Teumer A;Tracy RP;Launer LJ;Buring JE;Yamamoto JF;Folsom AR;Sijbrands EJ;Pankow J;Elliott P;Keaney JF;Sun W;Sarin AP;Fontes JD;Badola S;Astor BC;Hofman A;Pouta A;Werdan K;Greiser KH;Kuss O;Meyer zu Schwabedissen HE;Thiery J;Jamshidi Y;Nolte IM;Soranzo N;Spector TD;Völzke H;Parker AN;Aspelund T;Bates D;Young L;Tsui K;Siscovick DS;Guo X;Rotter JI;Uda M;Schlessinger D;Rudan I;Hicks AA;Penninx BW;Thorand B;Gieger C;Coresh J;Willemsen G;Harris TB;Uitterlinden AG;Järvelin MR;Rice K;Radke D;Salomaa V;Willems van Dijk K;Boerwinkle E;Vasan RS;Ferrucci L;Gibson QD;Bandinelli S;Snieder H;Boomsma DI;Xiao X;Campbell H;Hayward C;Pramstaller PP;van Duijn CM;Peltonen L;Psaty BM;Gudnason V;Ridker PM;Homuth G;Koenig W;Ballantyne CM;Witteman JC;Benjamin EJ;Perola M;Chasman DI
通讯作者：
Chasman DI
影响因子：
3.3
作者：
Felger JC;Lotrich FE
通讯作者：
Lotrich FE
影响因子：
5.8
作者：
Hage, Fadi G.;Szalai, Alexander J.
通讯作者：
Szalai, Alexander J.
影响因子：
4.8
作者：
Beluche, Isabelle;Chaudieu, Isabelle;Ancelin, Marie L.
通讯作者：
Ancelin, Marie L.
影响因子：
7.4
作者：
Handa RJ;Weiser MJ
通讯作者：
Weiser MJ