Epidemiological aspects of rotavirus and adenovirus in hospitalized children with diarrhea: a 5-year survey in Beijing.
Epidemiological aspects of rotavirus and adenovirus in hospitalized children with diarrhea: a 5-year survey in Beijing.
复制标题
北京市住院腹泻儿童轮状病毒和腺病毒5年流行病学调查.
DOI：
10.1186/s12879-016-1829-z
复制
发表时间：
2016-09-23
影响因子：
3.7
通讯作者：
Dong H
中科院分区：
文献类型：
--
作者：
Liu L;Qian Y;Zhang Y;Zhao L;Jia L;Dong H
由病毒引起的腹泻是一个全球性的问题，在幼儿。我们调查了两种最重要的病原体，轮状病毒和腺病毒，为更好地了解它们在儿童急性腹泻中的作用提供流行病学证据。2010 ~ 2014年共纳入3147例住院儿童。对从参与者收集的粪便标本进行轮状病毒抗原检测和腺病毒DNA检测。社区获得性腹泻（CAD）1985例，医院获得性腹泻（HAD）1162例。轮状病毒阳性692例（22.0%）.在HAD患儿中检出轮状病毒的比例高于CAD患儿（24.6%; 286/1162 vs. 20.5%; 406/1985）。腺病毒阳性324例（10.3%）. CAD组与HAD组之间存在显著差异（9.5%; 188/1985 vs. 11.7%; 136/1162：χ2 = 3.957，p = 0.047）。仅35例儿童（1.11%）发现合并感染，CAD组和HAD组的合并感染率相似（χ2 = 1.174，p = 0.279）。性别与这些病毒的检出率之间没有关联。冠心病组轮状病毒阳性率差异有显著性（χ2 = 27.979，p < 0.001），腺病毒阳性率差异有显著性（χ2 = 34.362，p < 0.001）。与其他四个年龄组（15. 8 - 19. 8%）相比，轮状病毒的患病率在12-24个月的儿童中最高（28. 6%）。在3.6%的新生儿中检测到腺病毒，而在1至6个月的婴儿中为5.8%;在6个月以上的儿童中增加到12.0- 13.8%。在HAD病例中，未发现轮状病毒和腺病毒的年龄差异。观察到轮状病毒的季节性变化，11月和12月为高峰，7月和8月为结束;但腺病毒没有发现明显的季节性模式。HAD患儿的轮状病毒和腺病毒检出率明显高于CAD患儿，但合并感染率很低。在新生儿腹泻中发现轮状病毒的高患病率。新生儿应考虑接种轮状病毒胃肠炎疫苗。本文的在线版本（doi：10.1186/s12879-016-1829-z）包含补充材料，可供授权用户使用。
Diarrhea caused by viruses is a global problem among young children. We investigated two of the most important agents, rotavirus and adenovirus, to provide epidemiological evidence for a better understanding of their role among children with acute diarrhea. A total of 3147 hospitalized children were enrolled in the study during 2010 ~ 2014. Antigen testing for rotavirus and DNA testing for adenovirus were performed on stool specimens collected from participants. There were 1985 cases of community-acquired diarrhea (CAD) and 1162 cases of hospital-acquired diarrhea (HAD). A total of 692 cases (22.0 %) were positive for rotavirus. Rotavirus was detected in more children with HAD than in those with CAD (24.6 %; 286/1162 vs. 20.5 %; 406/1985). A total of 324 cases (10.3 %) were adenovirus positive. There was a significant difference between the CAD group and HAD group (9.5 %; 188/1985 vs. 11.7 %; 136/1162: χ2 = 3.957, p = 0.047). Co-infection was found in only 35 children (1.11 %), and the co-infection rate was similar between the CAD and HAD groups (χ2 = 1.174, p = 0.279). There was no association between sex and the detection rate of these viruses. The positive rate was significantly different for rotavirus among CAD cases (χ2 = 27.979, p < 0.001) and for adenovirus (χ2 = 34.362, p < 0.001) in the five age groups. Compared with the other four age groups (15.8–19.8 %), the prevalence of rotaviruses was highest among children aged 12–24 months (28.6 %). Adenovirus was detected in 3.6 % of neonates compared with 5.8 % of infants from 1 to 6 months old; this increased to 12.0–13.8 % in children over 6 months of age. In HAD cases, age differences were not found for rotavirus and adenovirus. Seasonal variation of rotavirus was observed, with peaks in November and December and with through in July and August; however, no clear seasonal pattern was found for adenovirus. Detection rates for rotavirus and adenovirus were significantly higher in children with HAD than those with CAD, but co-infection was very low. A high prevalence of rotavirus was identified in neonates with diarrhea. Vaccination for rotavirus gastroenteritis should be considered in neonates. The online version of this article (doi:10.1186/s12879-016-1829-z) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
3.7
作者：
Liu L;Qian Y;Zhang Y;Deng J;Jia L;Dong H
通讯作者：
Dong H
影响因子：
6.4
作者：
Duan, Zhao-jun;Liu, Na;Fang, Zhao-Yin
通讯作者：
Fang, Zhao-Yin
影响因子：
168.9
作者：
Armah, George E.;Sow, Samba O.;Neuzil, Kathleen M.
通讯作者：
Neuzil, Kathleen M.
影响因子：
8.8
作者：
Jin, Yu;Cheng, Wei-xia;Duan, Zhao-jun
通讯作者：
Duan, Zhao-jun
影响因子：
5.1
作者：
Bines, Julie E.;Liem, Nguyen Thanh;Carlin, John B.
通讯作者：
Carlin, John B.