Comparative histopathology and immunohistochemistry of QX-like, Massachusetts and 793/B serotypes of infectious bronchitis virus infection in chickens.
Comparative histopathology and immunohistochemistry of QX-like, Massachusetts and 793/B serotypes of infectious bronchitis virus infection in chickens.
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DOI：
10.1016/j.jcpa.2010.04.007
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发表时间：
2010-11
影响因子：
0.8
通讯作者：
Palya V
中科院分区：
文献类型：
--
作者：
Benyeda Z;Szeredi L;Mató T;Süveges T;Balka G;Abonyi-Tóth Z;Rusvai M;Palya V
本研究的目的是通过实验比较新近出现的鸡传染性支气管炎病毒（IBV）QX样株与流行的M41和793/B血清型的致病性和组织分布。采用组织学和免疫组织化学方法确定病毒复制的主要部位。用5种不同的QX样毒株或M41和793/B IBV毒株接种1日龄无特定病原体的鸡，并在感染后监测42天。所有感染的禽类均出现气管病变，证实了所有受试菌株诱导呼吸道疾病的能力。消化道中的分离株的复制被检测到，但感染并没有引起显着的肠道病变。5株QX样IBV中有4株引起严重的肾脏病变。在用所有五种QX样毒株实验感染后，观察到输卵管扩张，在该结构的管腔中积累血清样液体，这是以前从QX样IBV感染的现场病例中报道的。受影响的输卵管的显微镜和免疫组化检查没有帮助阐明这种病变的发病机制。
The aim of this study was to compare experimentally the pathogenicity and tissue distribution of the recently emerged QX-like strain of infectious bronchitis virus (IBV) with the widespread M41 and 793/B serotypes of the virus. Histopathological and immunohistochemical methods were employed to define the main sites of virus replication. One-day-old specific pathogen free chickens were inoculated with five different QX-like strains, or with the M41 and 793/B IBV strains and monitored for 42 days post-infection. Tracheal lesions developed in all infected birds, confirming the ability of all of the tested strains to induce respiratory disease. Replication of the isolates in the alimentary tract was detected, but the infection did not cause significant gut lesions. Four of the five QX-like IBV strains induced severe kidney lesions. Dilation of the oviduct with accumulation of serum-like fluid in the lumen of this structure, reported previously from field cases of QX-like IBV infection, was observed following experimental infection with all of the five QX-like strains. Microscopical and immunohistochemical examination of the affected oviducts did not help to elucidate the pathogenesis of this lesion.
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影响因子：
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通讯作者：
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